HE Chunshui , HE Yanzheng , TIAN Gendong , ZHONG Wu
  • Department of Vascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou 646000,China;
Orthotopic liver transplantation; Pig; Extracorporeal venovenous bypass
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ObjectiveTo explore the application of extracorporeal venovenous bypass in orthotopic liver transplantation in pigs and to compare hemodynamic changes during operation of two different bypass ways. MethodsTwentyfive porcine orthotopic liver transplantations were performed and extracorporeal venovenous bypass was established during anhepatic phase through a catheter in portal vein (group A,n=16) or in splenic vein (group B,n=9).Hemodynamic changes were monitored continuously.ResultsFourteen recipients survived two days after operation (14/16) in group A while all survived in group B (9/9).Transient hemodynamic disturbance (MAP and CVP decreased,and HR increased) was monitored at both the beginning and the end of anhepatic stage in group A,while these parameters kept stable in group B (P＜0.05).ConclusionApplying venovenous bypass may stabilize recipients’ hemodynamics in porcines orthotopic liver transplantation,and splenic vein draining way has more advantages than portal vein.

Citation： HE Chunshui,HE Yanzheng,TIAN Gendong,ZHONG Wu. Extracorporeal Venous Bypass in Porcine Orthotopic Liver Transplantation: A Comparative Study. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 125-127. doi: Copy