The Role of Transforming Growth Factorβ in Transplant Rejection_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of HepatoBilioPancreatology 1,The Second Affiliated Hospital,Kunming Medical College,Kunming 650101, China;

Corresponding author：

Keywords：

Transforming growth factor β; Graft rejection; Gene polymorphism

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo introduce transforming growth factor β(TGFβ) and the relationship between TGFβ and graft rejection. Methods Relevent articles in recent years were reviewed.ResultsThe immunodepressive function of TGFβ could resist transplant organ rejection injury in early postoperative period ; meanwhile TGFβ also caused fibroblast migration and promoted matrix deposition by increasing collagen production and decreasing collagen breakdown via inhibition of collagenases,which resulted in transplant organ fibrosis and arteriosclerosis, gene polymorphisms of the TGFβ were associated with it. Moreover,ischemia reperfusion injury and immunodepressive drug also affected production of TGFβ.ConclusionTGFβ as a pleiotropic and multifunctional cytokine contributes to the development of acute and chronic rejection.

Citation： JIANG Nan,LI Li. The Role of Transforming Growth Factorβ in Transplant Rejection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(2): 179-181. doi: Copy

1.	Wallick SC,Figari IS,Morris RE,et al.Immunoregulatory role of transforming growth factor beta(TGFbeta)in development of killer cells: comparison of active and latent TGFbeta 1[Ｊ]. J Exp Med， 1990； 172(6)∶1777.
2.	Waltenberger J,Wanders A,Fellstrom B,et al.Induction of transforming growth factorbeta during cardiac allgraft rejection[Ｊ]. J Immunol，1993； 151(2)∶1147.
3.	Qin L,Chavin KD,Ding Y,et al.Gene transfer for transplantation. Prolongation of allograft survival with transforming growth factorbeta 1 [Ｊ]. Ann Surg，1994; 220(4)∶508.
4.	Isaka Y,Fujiwara Y,Ueda N,et al.Glomerulosclerosis induced by in vivo transfection of transforming growth factorbeta or plateletderived growth factor gene into the rat kidney [Ｊ]. J Clin Invest， 1993; 92(6)∶2597.
5.	Yamamoto T,Noble NA,Miller DE,et al.Sustained expression of TGFbeta 1 underlies development of progressive kidney fibrosis[Ｊ]. Kidney Int，1994; 45(3)∶916.
6.	Sharma VK,Bologa RM, Xu GP,et al.Intragraft TGFbeta1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy[Ｊ]. Kidney Int，1996; 49(5)∶1297.
7.	Sankaran D, Asderakis A, Asharaf S, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation[Ｊ]. Kidney Int, 1999; 56(1)∶281.
8.	ElGamel A,Sim E,Hasleton P,et al.Transforming growth factor beta(TGFbeta) and obliterative bronchiolitis following pulmnary transplantation[Ｊ]. J Heart Lung transplant，1999; 18(9)∶828.
9.	Charpin JM,Valcke J,Kettaneh L,et al.Peaks of transforming growth factorbeta mRNA in alveoral cells of lung transplant recipients as an early marker of chronic rejection[Ｊ]. Transplantation,1998; 65(5)∶752.
10.	ElGamel A,Awad M,Sim E,et al.Transforming growth factorbeta1 and lung allograft fibrosis[Ｊ]. Eur J Cardiothorac Surg，1998; 13(4)∶424.
11.	Awad MR,ElGamel A,Hasleton P,et al. Genotypic variation in the transforming growth factorbeta1 gene: association with transforming growth factorbeta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation [Ｊ]. Transplantation,1998; 66(8)∶101.
12.	ElGamel A,Awad MR,Hasleton PS,et al.Transforming growth factorbeta (TGFbeta) genotype and lung allograft fibrosis[Ｊ]. J Heart Lung Transplant, 1999; 18(6)∶517.
13.	De GrootKruseman HA,Baan CC,Mol WM,et al.Up regulated transforming growth factorbeta 1 mRNA expression in endomyocardial biopsies during the development of graft vascular disease after clinical heart transplantation[Ｊ]. Transplant Proc,1999; 31(7)∶2724.
14.	Aziz T,Hasleton P,Hann AW,et al.Transforming growth factor beta in relation to cardiac allograft vasculopathy after heart transplantation[Ｊ]. J Thorac Cardiovasc Surg，2000; 119(4 pt 1)∶700.
15.	Densem CG,Hutchinson IV,Cooper A,et al.Polymorphism of the transforming growth factorbeta1 gene correlates with the development of coronary vasculopathy following cardiac transplantation[Ｊ]. J Heart Lung Transplant,2000; 19(6)∶551.
16.	Demirci G,Nashan B,Pichlmayr R.Fibrosis in chronic rejection of human liver allografts:expression patterns of transforming growth factor TGFbeta1 and TGFbeta3[Ｊ]. Transplantation,1996; 62(12)∶1776.
17.	Hadley GA,Rostapshova EA,Gomolka DM,et al.Regulation of the epithelial cellspecific integin,CD103,by human CD8+ cytolytic T lymphocytes[Ｊ]. Transplantation,1999; 67(11)∶1418.
18.	Robertson H, Wong WK,Talbot D,et al.Tubulitis after renal transplantation:demonstration of an association between CD103+ T cells,transforming growth factor beta1 expression and rejection grade[Ｊ]. Transplantation,2001; 71(2)∶306.
19.	Basile DP,Rovak JM,Martin DR,et al.Increased transforming growth factorbeta1 expression in regenerating rat renal tubules following ischemia injury[Ｊ]. Am J Physiol,1996; 270（3 Pt 2）∶F500.
20.	Mohamed MA,Robertson H,Booth TA,et al.TGFbeta expression in renal transplant biopsies:a comparative study between cyclosporinA and tacrolimus[Ｊ]. Transplantation,2000; 69（5）∶1002.
21.	Hutchinson IV.The role of transforming growth factorbeta in transplant rejection[Ｊ]. Transplant Proc,1999; 31(7A)∶9S.
22.	Khanna A,Cairns V,Hosenpud JD.Tacrolimus induces increased expression of transforming growth factorbeta1 in mammalian lymphoid as well as nonlymploid cells[Ｊ]. Transplantation,1999; 67（4）∶614.
23.	Hughes JR,Hughes VF,Trull AK,et al.Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus of microemulsified cyclosporine[Ｊ]. Transplantation,1999; 68（4）∶583.

1. Wallick SC,Figari IS,Morris RE,et al.Immunoregulatory role of transforming growth factor beta(TGFbeta)in development of killer cells: comparison of active and latent TGFbeta 1[Ｊ]. J Exp Med， 1990； 172(6)∶1777.
2. Waltenberger J,Wanders A,Fellstrom B,et al.Induction of transforming growth factorbeta during cardiac allgraft rejection[Ｊ]. J Immunol，1993； 151(2)∶1147.
3. Qin L,Chavin KD,Ding Y,et al.Gene transfer for transplantation. Prolongation of allograft survival with transforming growth factorbeta 1 [Ｊ]. Ann Surg，1994; 220(4)∶508.
4. Isaka Y,Fujiwara Y,Ueda N,et al.Glomerulosclerosis induced by in vivo transfection of transforming growth factorbeta or plateletderived growth factor gene into the rat kidney [Ｊ]. J Clin Invest， 1993; 92(6)∶2597.
5. Yamamoto T,Noble NA,Miller DE,et al.Sustained expression of TGFbeta 1 underlies development of progressive kidney fibrosis[Ｊ]. Kidney Int，1994; 45(3)∶916.
6. Sharma VK,Bologa RM, Xu GP,et al.Intragraft TGFbeta1 mRNA: a correlate of interstitial fibrosis and chronic allograft nephropathy[Ｊ]. Kidney Int，1996; 49(5)∶1297.
7. Sankaran D, Asderakis A, Asharaf S, et al. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation[Ｊ]. Kidney Int, 1999; 56(1)∶281.
8. ElGamel A,Sim E,Hasleton P,et al.Transforming growth factor beta(TGFbeta) and obliterative bronchiolitis following pulmnary transplantation[Ｊ]. J Heart Lung transplant，1999; 18(9)∶828.
9. Charpin JM,Valcke J,Kettaneh L,et al.Peaks of transforming growth factorbeta mRNA in alveoral cells of lung transplant recipients as an early marker of chronic rejection[Ｊ]. Transplantation,1998; 65(5)∶752.
10. ElGamel A,Awad M,Sim E,et al.Transforming growth factorbeta1 and lung allograft fibrosis[Ｊ]. Eur J Cardiothorac Surg，1998; 13(4)∶424.
11. Awad MR,ElGamel A,Hasleton P,et al. Genotypic variation in the transforming growth factorbeta1 gene: association with transforming growth factorbeta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation [Ｊ]. Transplantation,1998; 66(8)∶101.
12. ElGamel A,Awad MR,Hasleton PS,et al.Transforming growth factorbeta (TGFbeta) genotype and lung allograft fibrosis[Ｊ]. J Heart Lung Transplant, 1999; 18(6)∶517.
13. De GrootKruseman HA,Baan CC,Mol WM,et al.Up regulated transforming growth factorbeta 1 mRNA expression in endomyocardial biopsies during the development of graft vascular disease after clinical heart transplantation[Ｊ]. Transplant Proc,1999; 31(7)∶2724.
14. Aziz T,Hasleton P,Hann AW,et al.Transforming growth factor beta in relation to cardiac allograft vasculopathy after heart transplantation[Ｊ]. J Thorac Cardiovasc Surg，2000; 119(4 pt 1)∶700.
15. Densem CG,Hutchinson IV,Cooper A,et al.Polymorphism of the transforming growth factorbeta1 gene correlates with the development of coronary vasculopathy following cardiac transplantation[Ｊ]. J Heart Lung Transplant,2000; 19(6)∶551.
16. Demirci G,Nashan B,Pichlmayr R.Fibrosis in chronic rejection of human liver allografts:expression patterns of transforming growth factor TGFbeta1 and TGFbeta3[Ｊ]. Transplantation,1996; 62(12)∶1776.
17. Hadley GA,Rostapshova EA,Gomolka DM,et al.Regulation of the epithelial cellspecific integin,CD103,by human CD8+ cytolytic T lymphocytes[Ｊ]. Transplantation,1999; 67(11)∶1418.
18. Robertson H, Wong WK,Talbot D,et al.Tubulitis after renal transplantation:demonstration of an association between CD103+ T cells,transforming growth factor beta1 expression and rejection grade[Ｊ]. Transplantation,2001; 71(2)∶306.
19. Basile DP,Rovak JM,Martin DR,et al.Increased transforming growth factorbeta1 expression in regenerating rat renal tubules following ischemia injury[Ｊ]. Am J Physiol,1996; 270（3 Pt 2）∶F500.
20. Mohamed MA,Robertson H,Booth TA,et al.TGFbeta expression in renal transplant biopsies:a comparative study between cyclosporinA and tacrolimus[Ｊ]. Transplantation,2000; 69（5）∶1002.
21. Hutchinson IV.The role of transforming growth factorbeta in transplant rejection[Ｊ]. Transplant Proc,1999; 31(7A)∶9S.
22. Khanna A,Cairns V,Hosenpud JD.Tacrolimus induces increased expression of transforming growth factorbeta1 in mammalian lymphoid as well as nonlymploid cells[Ｊ]. Transplantation,1999; 67（4）∶614.
23. Hughes JR,Hughes VF,Trull AK,et al.Blood levels of TGFbeta1 in liver transplant recipients receiving either tacrolimus of microemulsified cyclosporine[Ｊ]. Transplantation,1999; 68（4）∶583.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Role of Transforming Growth Factorβ in Transplant Rejection

Abstract Full text Figures/Tables Video References Cited by

Format

Content