Study the Different Biology Behavior of Typical Breast Medullary Carcinoma and Atypical Medullary Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Xiaoming ¹ , WEN Lichao ¹ , ZHU Renzhi. ²

Department of Pathology, Lanzhou Medical College, Lanzhou 730030, China;

Corresponding author：

Keywords：

Medullary breast carcinoma; Ecadherin; βcatenin; Immunohistochemistry

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

ObjectiveTo study the cause of different prognosis in typical medullary carcinoma and atypical medullary carcinoma. MethodsThe immunohistochemical staining method was used to evaluate the positivity of Ecadherin,βcatenin, in 30 cases of atypical medullary carcinoma and 18 cases of typical medullary carcinoma and 10 cases of normal breast. ResultsThe positive rate and staining intensity of Ecadherin and βcatenin oncoprotein were significantly higher in typical medullary carcinoma than in atypical medullary carcinoma(P lt;0.01).ConclusionExpression of Ecadherin and βcatenin is one of the causes of similar morphology and different prognosis in medullary breast carcinoma.

Citation： LI Xiaoming,WEN Lichao,ZHU Renzhi.. Study the Different Biology Behavior of Typical Breast Medullary Carcinoma and Atypical Medullary Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(3): 268-269. doi: Copy

1.	Ridolfi RL, Rosen PP, Port A, et al. Medullary carcinoma of the breast: a clinicopathologic study with 10 year followup[J]. Cancer, 1977; 40（4）∶1365.
2.	Rapin V, Contesso G, Mouriesse H, et al. Medullary breast carcinoma. A reevaluation of 95 cases of breast cancer with inflammatory stroma[J]. Cancer, 1988； 61（12）∶2503.
3.	Charpin C, Bonnier P, Garcia S, et al. Ecadherin and betacatenin expression in breast medullary carcinomas[J]. Int J Oncol, 1999; 15(2)∶285.
4.	Grabsch H, Takeno S, Noguchi T， et al. Different patterns of betacatenin expression in gastric carcinomas: relationship with clinicopathological parameters and prognostic outcome [J]. Histopathology， 2001; 39(2)∶141.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study the Different Biology Behavior of Typical Breast Medullary Carcinoma and Atypical Medullary Carcinoma

Abstract Full text Figures/Tables Video References Cited by

Format

Content