Study on Relationship Between Orthotopic Liver Transplantation with or Without Preservation of Retrohepatic Vena Cava and Postoperative Allograft Hepatitis B Virus Reinfection_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaobo , LU Shichun , YAN Lnan , LI Bo , WEN Tianfu , LIN Qiyuan , ZENG Yong , ZHAO Jichuan , LAI Wei , LIU Jun

Department of General Surgery, West China Hospital,Sichuan University, Chengdu 610041, China;

Corresponding author：

Keywords：

Liver transplantation，Retrohepatic vena cava，Hepatitis B virus，Recurrence

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ObjectiveTo explore the relationship between liver transplantation procedure with or without preservation of retrohepatic vena cava and postoperative reinfection of hepatitis B virus.MethodsHepatitis B virus makers of 15 retrohepatic vena cava samples from hepatitis B virus active replicating recipients was detected using immunohistochemistry stain LSAB and HBV DNA hybridization in situ. Hepatitis B virus reinfection rate and survival rate after transplantation in classic group (20 cases) and piggyback group (7 cases) was analyzed retrospectively. ResultsHepatitis B virus makers including HBsAg and HBcAg and HBV DNA of all 15 retrohepatic vena cava samples, 10 from classic group and 5 from piggyback group, was negative. In classic group, 20 recipients were followedup 6-30 months, mean 18 months, only one case of hepatitis B recurrence was confirmed 22 months after operation; In piggyback group,7 recipients were followedup 5-12 months, mean 8 months, none of hepatitis B virus reinfection was encountered. Recurrence rate in classic group and piggyback group was 5.0%(1/20) and 0(0/7), respectively.ConclusionThis preliminary study indicated that the retrohepatic vena cava of hepatitis B virus active replicating recipients don’t have the residence and replication of hepatitis B virus particle. Orthotopic liver transplantation procedure with preservation of retrohepatic vena cava appears not to increase the hepatitis B virus reinfection rate in hepatitis B virus active replicating recipients after transplantation.

Citation： WANG Xiaobo,LU Shichun,YAN Lnan,LI Bo,WEN Tianfu,LIN Qiyuan,ZENG Yong,ZHAO Jichuan,LAI Wei,LIU Jun. Study on Relationship Between Orthotopic Liver Transplantation with or Without Preservation of Retrohepatic Vena Cava and Postoperative Allograft Hepatitis B Virus Reinfection. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 340-342. doi: Copy

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1. Samuel D, Bismuth A, Mathieu D, et al. Passive immunoprophylaxis after liver transplantation in HBsAgpositive patients [J]. Lancet, 1991; 337(8745)∶813.
2. Dejean A, Lugassy C, Zafrani S, et al. Detection of hepatitis B virus DNA in pancreas, kidney and skin of two human carriers of virus [J]. J Gen Virol, 1984; 65(Pt 3)∶651.
3. 卢实春，严律南，李波，等. 拉未夫定预防乙肝相关性肝硬化肝移植术后乙肝再感染的临床对照研究 [J]. 世界华人消化杂志， 2003; 11(2)∶185.
4. 卢实春，严律南，李波，等. HBV复制活跃肝移植受体在拉咪呋啶预防下HBV标志物动态变化的研究 [J]. 肝脏， 2002; 7(2)∶76.
5. BenAri Z, Shmuel D, Mor E, et al. Beneficial effect of lamivudine in recurrent hepatitis B after liver transplantation [J]. Transplantation， 1997; 63(3)∶393.
6. Petit MA, BuffelloLe Guillou D, Roche B, et al. Residual hepatitis B virus particles in liver transplant recipients receiving lamivudine: PCR quantitation of HBV DNA and ELISA of preS1 antigen [J]. J Med Virol, 2001; 65(3)∶493.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Study on Relationship Between Orthotopic Liver Transplantation with or Without Preservation of Retrohepatic Vena Cava and Postoperative Allograft Hepatitis B Virus Reinfection

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