Expression of HOX A9 mRNA and Its Clinicopathological Significance in Benign and Malignant Lesions of Pancreas_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Qunwei , YANG Zhulin , MIAO Xiongying , LIU Guoli , LI Yongguo

Research Lab of Hepatobiliary Diseases, The Second Xiangya Hospital of Central South University, Changsha 410011, China;

Corresponding author：

Keywords：

Pancreatic neoplasms; Chronic pancreatitis; Homeobox genes; Situ hybridization

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ObjectiveTo study the expression of HOX A9 mRNA and its clinicopathological significance in the benign and malignant lesions of pancreas. MethodsIn situ hybridization for HOX A9 mRNA was used on routine paraffinembedded sections. ResultsThe positive rate and scoring mean of HOX A9 mRNA expression was significanfly lower in pancreatic carcinoma (49%, 3.3±2.1) than that in chronic pancreatitis (95%, 5.4±0.8) and pericancerous tissues (80%, 4.6±1.2), the negative case of HOX A9 mRNA in chronic pancreatitis and pericancerous tissues showed middle or severelyatypical hyperplasis of the ductal epitheli. The positive rate and scoring mean of HOX A9 mRNA expression was significantly higher in the cases of welldifferentiation (63%, 4.0±2.2) or without metastasis (64%, 4.1±2.2) than that in the ones of poorlydifferentiation (32%, 2.6±2.3) or with metastasis (32%, 2.7±2.2). ConclusionThe expression of HOX A9 mRNA might be related the carcinogenesis, progress, biological behaviors, and prognosis of pancreatic carcinoma. The assay of HOX A9 mRNA expression in the benign lesions of pancreas might have important clinical values in the prevention and earlystage finding of the pancreatic carcinoma.

Citation： WANG Qunwei,YANG Zhulin,MIAO Xiongying,LIU Guoli,LI Yongguo. Expression of HOX A9 mRNA and Its Clinicopathological Significance in Benign and Malignant Lesions of Pancreas. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(4): 373-375. doi: Copy

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1. Golpon HA, Geraci MW, Moore MD, et al.Hox genes in human lung: altered expression in primary pulmonary hypertension and emphysema [J]. Am J Pathol, 2001; 158(3)∶ 955.
2. Raman V, Martensen SA, Reisman D, et al. Compromised HOX A5 function can limit p53 expression in human breast tumours [J]. Nature, 2000; 405(6789)∶974.
3. Cillo C, Cantile M, Faiella A, et al. Homeobox genes in normal and malignant cells [J]. J Cell Physiol, 2001; 188( 2) ∶161.
4. Li H, Huang CJ, Choo KB. Expression of homeobox genes in cervical cancer [J]. Gynecol Oncol, 2002; 84(2)∶ 216.
5. 胡淳玲，喻伦银，陈德基, 等. 大鼠试验性肺鳞癌癌变各阶段间质微血管密度及VEGF、FLK1表达的动态变化 [J]. 癌症， 2001; 20(10)∶713.
6. Pando SM, Taylor HS. Homeobox gene expression in ovarian cancer [J]. Cancer Treat Res, 2002; 107∶231.
7. Afonja O, Smith JE Jr, Cheng DM, et al. MEISI and HOXA7 genes in man acute myeloid leukemia [J]. Leuk Res, 2000; 24(10)∶849.
8. Wang Y, Hung C, Koh D, et al. Differential expression of HOX A5 in human colon cancer cell differentiation: a quantitative study using realtime RTPCR [J]. Int J Oncol, 2001; 18(3)∶617.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of HOX A9 mRNA and Its Clinicopathological Significance in Benign and Malignant Lesions of Pancreas

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