Effect of Preoperative Regional IntraArterial Infusion Chemotherapy on the Prognosis of Advanced Gastric Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

ZHANG Chengwu , ZOU Shouchun , QIU Huasen , ZHAO Dajian

Department of General Surgery, Zhejiang Provincial People’s Hospital, Hangzhou 310014, China;

Corresponding author：

Keywords：

Stomach neoplasmIntraarterial chemotherapyPrognosisCox regression analysis

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ObjectiveTo evaluate the effect of preoperative regional intraarterial infusion chemotherapy on the prognosis of advanced gastric cancer. MethodsThe clinical data of 80 patients who underwent curative resection for advanced gastric cancers were summarized.Among them,33 patients carried out preoperative regional intraarterial infusion chemotherapy were as the interventional chemotherapy group,and the remaining 47 patients were the control group.Eleven factors including clinical and pathological data,treatment procedures and molecular biological makers that contributed to the longterm survival rate were analyzed by Cox multivariate regression analysis.ResultsThe 5year survival rate of the interventional group was 59.3%,and the control group 47.6%.There was significant difference between two groups (P＜0.05).Multivariate regression analysis revealed that the preoperative regional intraarterial infusion chemotherapy was one of the independent factors affecting the longterm survival of patients with advanced gastric cancers.ConclusionThe preoperative regional intraarterial infusion chemotherapy has important value for improving the prognosis of gastric cancer.

Citation： ZHANG Chengwu,ZOU Shouchun,QIU Huasen,ZHAO Dajian. Effect of Preoperative Regional IntraArterial Infusion Chemotherapy on the Prognosis of Advanced Gastric Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2003, 10(5): 480-481. doi: Copy

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1. Allgayer H, Heiss MM, Schildberg FW. Prognostic factors in gastric cancer 　[J]. Br J Surg, 1997; 　84(12)∶1651.
2. 邹寿椿，裘华森，张成武，等. 胃癌围手术期三联序贯疗法的临床研究和随访 [J]. 中华消化杂志, 1999; 　19(3)∶210.
3. Tokairin Y, Maruyama M, Baba H, et al. Pharmacokinetics of “subselective” arterial infusion chemotherapy[J]. Gan To Kagaku Ryoho, 2001; 　28(11)∶ 1795.
4. Kosaka T, Ueshige N, Sugaya J, et al. Evaluation of intraarterial infusion chemotherapy for advanced gastric cancer[J]. Gan To Kagaku Ryoho, 1998; 　25(9)∶1288.
5. 刘福坤. 进展期胃癌手术前后介入治疗 [J]. 中国实用外科杂志,2001;　21(7)∶ 403.
6. Masuyama M, Taniguchi H, Takeuchi K, et al. Recurrence and survival rate of advanced gastric cancer after preoperative EAPⅡ intraarterial infusion therapy [J]. Gan To Kagaku Ryoho, 1994; 　21(13)∶2253.
7. Bozzetti F,Bonfanti G,Morabito A,et al. A multifactorial approach for the prognosis of patients with carcinoma of the stomach after curative resection[J]. Surg Gynecol Obstet, 1986;　162(3)∶229.
8. Hermanek P, Wittekind C. News of TNM and its use for classification of gastric cancer[J]. World J Surg, 1995; 　19(4)∶491.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Preoperative Regional IntraArterial Infusion Chemotherapy on the Prognosis of Advanced Gastric Cancer

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