Clinical Value of Microvessel Counts in Colorectal Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LEI Wen ¹ , YU Baoming ² , ZHOU Xigeng ²

Department of Oncology, Fujian Provincial Hospital, Fuzhou 350001;

Corresponding author：

Keywords：

Colorectal neoplasm; Angiogenesis; Prognosis

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Objective To determine whether tumor angiogenesis correlates with progression of colorectal carcinoma.
Methods Microvessel counts (MVC) of 102 specimens resected from patients with colorectal carcinoma were investigated by immunohistological staining with a monocolonal antibody against FⅧ RAg, the mean number of microvessels in three areas of highest vascular density were counted under 200 times magnification microscope. Correlation of MVC with various clinicopathologic factors, and prognosis was studied.
Results MVC was increased with Dukes stage, the MVC of patients with advanced stage disease was significantly higher than that of early stage patients (P＜0.01). MVC was significantly higher in tumors with lymph node metastasis and liver metastasis (P＜0.01) than in those without such metastasis. The recurrence rate after curative resection in hypervascular group (MVC≥14, 60.4%) was significantly higher (P＜0.01) than that in the hypovascular group (MVC＜14,26.5%).Moreover, the prognosis of patients with a high MVC was significantly poorer than that of those with a low MVC (P＜0.01).
Conclusion Angiogenesis within colorectal cancer is an indicator of tumor behavior and may identify patients at higher risk for recurrence and poorer prognosis.

Citation： LEI Wen,YU Baoming,ZHOU Xigeng. Clinical Value of Microvessel Counts in Colorectal Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(1): 40-42. doi: Copy

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6.	Maeda K ,Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [Ｊ]. Cancer, 1996; 77（5）∶858.
7.	Weidner N, Carroll PR, Flax J, et al. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma [Ｊ]. Am J Pathol, 1993; 143（2）∶401.
8.	Detmar M. Molecular regulation of angiogenesis in skin [Ｊ]. J Invest Dermatol, 1996; 106（1）∶207.
9.	Abdulrauf SI, Edvardsen K, Ho KL, et al. Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with lowgrade astrocytoma [Ｊ]. J Neurosurg,1998; 88（3）∶513.
10.	Volm M, Koomagi R, Kaufmann M, et al. Microvessel density, expression of protooncogenes, resistancerelated proteins and incidence of metastasis in primary ovarian carcinomas [Ｊ]. Clin Exp Metastasis, 1996; 14（2）∶209.
11.	Tomisaki S, Ohno S, Ichiyoshi Y, et al. Microvessel quantification and its possible relation with liver metastasis in colorectal cancer [Ｊ]. Cancer, 1996; 77（8 Suppl)∶1722.
12.	Bossi P,Viale G,Lee AK,et al.Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations [Ｊ]. Cancer Res, 1995; 55（21）∶5049.
13.	Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predictor of recurrence and survival in patients with nodenegative colon cancer [Ｊ]. Ann Surg, 1995; 222（6）∶695.
14.	Engel CJ, Bennett ST, Chambers AF, et al. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for dukes staging [Ｊ]. Am J Surg Pathol, 1996; 20（10）∶1260.
15.	Saclarides TJ, Speziale NJ, Drab E, et al. Tumor angiogenesis and rectal carcinoma [Ｊ]. Dis Colon Rectum,1994; 37（5）∶921.
16.	Takebayashi Y, Akiyama S, Yamada K, et al. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma [Ｊ]. Cancer, 1996; 78（2）∶226.
17.	Tanigawa N, Amaya H, Matsumura M, et al. Tumor angiogenesis and mode of metastasis in patients with colorectal cancer [Ｊ]. Cancer Res,1997; 57（6）∶1043.
18.	Nanashima A, Ito M, Sekine I, et al. Significance of angiogenic factors in liver metastatic tumors originating from colorectal cancers [Ｊ]. Dig Dis Sci, 1998; 43（12）∶2634.

1. Norton JA. Tumor angiogenesis [Ｊ]. Ann Surg, 1995; 222（6）∶693.
2. Mooteri H, Rubin D, Leurgans S, et al. Tumor angiogenesis in primary and metastatic colorectal cancers [Ｊ]. Dis Colon Rectum, 1996; 39（10）∶1073.
3. Weidner N, Folkman J, Pozza F, et al. Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [Ｊ]. J Natl Cancer Inst,1992; 84（8）∶1875.
4. Folkman J. Tumor angiogenesis and tissue factor [Ｊ]. Nature Medicine, 1996; 2（1）∶167.
5. Banner BF, Whitehouse R, Baker SP, et al. Tumor angiogenesis in stage II colorectal carcinoma association with survival [Ｊ]. Am J Clin Pathol, 1998; 109（6）∶733.
6. Maeda K ,Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma [Ｊ]. Cancer, 1996; 77（5）∶858.
7. Weidner N, Carroll PR, Flax J, et al. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma [Ｊ]. Am J Pathol, 1993; 143（2）∶401.
8. Detmar M. Molecular regulation of angiogenesis in skin [Ｊ]. J Invest Dermatol, 1996; 106（1）∶207.
9. Abdulrauf SI, Edvardsen K, Ho KL, et al. Vascular endothelial growth factor expression and vascular density as prognostic markers of survival in patients with lowgrade astrocytoma [Ｊ]. J Neurosurg,1998; 88（3）∶513.
10. Volm M, Koomagi R, Kaufmann M, et al. Microvessel density, expression of protooncogenes, resistancerelated proteins and incidence of metastasis in primary ovarian carcinomas [Ｊ]. Clin Exp Metastasis, 1996; 14（2）∶209.
11. Tomisaki S, Ohno S, Ichiyoshi Y, et al. Microvessel quantification and its possible relation with liver metastasis in colorectal cancer [Ｊ]. Cancer, 1996; 77（8 Suppl)∶1722.
12. Bossi P,Viale G,Lee AK,et al.Angiogenesis in colorectal tumors: microvessel quantitation in adenomas and carcinomas with clinicopathological correlations [Ｊ]. Cancer Res, 1995; 55（21）∶5049.
13. Frank RE, Saclarides TJ, Leurgans S, et al. Tumor angiogenesis as a predictor of recurrence and survival in patients with nodenegative colon cancer [Ｊ]. Ann Surg, 1995; 222（6）∶695.
14. Engel CJ, Bennett ST, Chambers AF, et al. Tumor angiogenesis predicts recurrence in invasive colorectal cancer when controlled for dukes staging [Ｊ]. Am J Surg Pathol, 1996; 20（10）∶1260.
15. Saclarides TJ, Speziale NJ, Drab E, et al. Tumor angiogenesis and rectal carcinoma [Ｊ]. Dis Colon Rectum,1994; 37（5）∶921.
16. Takebayashi Y, Akiyama S, Yamada K, et al. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma [Ｊ]. Cancer, 1996; 78（2）∶226.
17. Tanigawa N, Amaya H, Matsumura M, et al. Tumor angiogenesis and mode of metastasis in patients with colorectal cancer [Ｊ]. Cancer Res,1997; 57（6）∶1043.
18. Nanashima A, Ito M, Sekine I, et al. Significance of angiogenic factors in liver metastatic tumors originating from colorectal cancers [Ｊ]. Dig Dis Sci, 1998; 43（12）∶2634.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Value of Microvessel Counts in Colorectal Carcinoma

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