Expression of p53 and Vascular Endothelial Growth Factor and Its Correlation with Hematogenous Metastasis in Colorectal Cancer_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LI Jikun ¹ , ZHENG Miao ¹ , LI Yuanfang ² , et al ²

Department of Surgery, Shanghai First People’s Hospital, Shanghai 200080;

Corresponding author：

Keywords：

Colonic neoplasm; Rectal neoplasm; Metastasis; p53 protein; Vascular endothelial growth factor

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Objective To study the expression of p53 and vascular endothelial growth factor (VEGF) and its correlation with hematogenous metastasis in colorectal cancer. MethodsAvidinbiotin complex method was used to study the expression of p53 and VEGF in 79 cases of colorectal cancer.ResultsThe positive rates of p53 and VEGF were 48.1% and 58.2% respectively in 79 cases of colorectal cancer. p53 and VEGF expression were identical in 49 (62.0%) cases. There was significant association between p53 or VEGF expression and venous invasion or hematogenous metastasis (P＜0.05). The incidence of hematogenous metastasis in the p53（＋）/VEGF（＋） subgroup was 66.7% and was significantly higher than that in the p53（－）/VEGF（－） or p53（＋）/VEGF（－） subgroup （P＜0.01）. Neither synchronous nor metachronous hematogenous metastasis were found in the p53（－）/VEGF（－） subgroup.Conclusion The combination of p53 and VEGF expression is an important predictor for hematogenous metastasis in patients with colorectal cancer.

Citation： LI Jikun,ZHENG Miao,LI Yuanfang,et al. Expression of p53 and Vascular Endothelial Growth Factor and Its Correlation with Hematogenous Metastasis in Colorectal Cancer. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 112-114. doi: Copy

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1. Maeda K, Chung YS, Ogawa Y, et al. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma \[J\]. Cancer, 1996; 77(5)∶858.
2. Takahashi Y, Bueana CD, Cleary KR, et al. p53, vessel count,and vascular endothelial growth factor expression in human colon cancer \[J\]. Int J Cancer,1998; 79(1)∶34.
3. Yoshiji H, Gomez DE, Shibuya M, et al. Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer \[J\]. Cancer Res, 1996; 56(9)∶2013.
4. Porter PL, Gown AM. p53 expression in human malignant tumors \[J\]. Am J Pathol, 1992; 140(1)∶145.
5. Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients \[J\]. Cancer Res, 1995; 55(22)∶5217.
6. Yamamura T, Matsuzaki H, Suda T, et al. Clinicopathological variables and p53 overexpression as a combined prognosticator for hematogenic recurrence in colorectal cancer \[J\]. J Surg Oncol, 1999; 70(1)∶1.
7. Kieser A, Weich HA, Brandner G, et al. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression \[J\]. Oncogene, 1994; 9(3)∶963.
8. Steele RJC, Thompson AM, Hall PA, et al. The p53 tumour suppressor gene \[J\]. Br J Surg, 1998; 85(11)∶1460.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of p53 and Vascular Endothelial Growth Factor and Its Correlation with Hematogenous Metastasis in Colorectal Cancer

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