The Application of High Intensity Focused Ultrasound in the Tumor Treatment_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery,West China Hospital, Sichuan University, Chengdu 610041;

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High intensity focused ultrasound; Tumor treatment

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bjectiveTo evaluate the efficacy and limits of high intensity focused ultrasound (HIFU) in tumor treatment. MethodsThe references about the application of HIFU in tumor treatment in recent years were reviewed.ResultsHIFU caused localized hyperthermia at predictable depth in a few seconds to make the tumor tissue coagulative necrosis without injuring surrounding tissue. HIFU treatment had the advantages of low morbidity, noninvasiveness, avoidance of systemic side effects, and repeatitiveness. However, the utilization of HIFU sometimes could be limited by some factors such as imaging technique, organ movement, incomplete tissue destruction, etc.ConclusionHIFU is a promising noninvasive therapy for tumor treatment, though there are lots of problems to be further studied.

Citation： LI Zhiyu,HE Sheng. The Application of High Intensity Focused Ultrasound in the Tumor Treatment. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(2): 139-141. doi: Copy

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15.	Prat F, Centarti M, Sibille A, et al. Extracorporeal highintensity focused ultrasound for VX2 liver tumors in the rabbit \[J\]. Hepatology, 1995; 21(3)∶832.
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1. Hill CR, Haar GR. Review article: high intensity focused ultrasoundpotential for cancer treatment \[J\]. Br J Radiol, 1995; 68(816)∶1296.
2. 伍烽，陈文直，白晋，等. 高强度聚焦超声治疗原发性肝癌的初步临床研究 \[J\]. 中华医学影像学杂志， 1999； 8（1）∶213.
3. Chapelon JY, Ribault M, Vernier F, et al. Treatment of localized prostate cancer with transrectal high intensity focused ultrasound \[J\]. Eur J Ultrasound, 1999; 9(1)∶314Chaussy CG, Thuroff S. Highintensity focused ultrasound in localized prostate cancer \[J\]. J Endourol, 2000; 14(3)∶293.
4. Gelet A, Chapelon JY, Bouvier R, et al. Local control of prostate cancer by transrectal high intensity focused ultrasound therapy: preliminary results \[J\]. J Urol, 1999; 161(1)∶156.
5. Beerlage HP,Thuroff S,Debruyne FMJ,et al.Transrectal highintensity focused ultrasound using the ablatherm device in the treatment of localized prostate carcinoma \[J\]. Urology, 1999; 54(2)∶273.
6. Sanghvi NT, Foster RS, Bihrle R, et al. Noninvasive surgery of prostate tissue by high intensity focused ultrasound: an updated report \[J\]. Eur J Ultrasound, 1999; 9(1)∶19.
7. Madersbacher S, Schatzl G, Djavan B, et al. Longterm outcome of transrectal highintensity focused ultrasound therapy for benign prostatic hyperplasia \[J\]. Eur Urol, 2000; 37(6)∶687.
8. Uchida T, Muramoto M, Kynnou H, et al. Clinical outcome of highintensity focused ultrasound for treating benign prostatic hyperplasia: preliminary report \[J\]. Urology, 1998; 52(1)∶66.
9. Yang R, Clarence R, Reilly FJ, et al. Effects of highintensity focused ultrasound in the treatment of experimental neuroblastoma \[J\]. J Ped Surg, 1992; 27(2)∶ 246.
10. 贾瑞鹏，周性名，张忠林，等.高强度聚焦超声对小鼠移植性膀胱肿瘤的杀伤效应及免疫功能的影响 \[J\]. 中华泌尿外科杂志， 1998； 19（6）∶ 270.
11. Barkman CA, Almquist LO, Kirkhorn T, et al. Thermotherapy: feasibility study using a single focused ultrasound transducer \[J\]. Int J Hyperthermia, 1999; 15(1)∶ 63.
12. 程树群，周信达，汤钊猷，等. 高功率聚焦超声高温破坏肝肿瘤的病理学改变 \[J\]. 中华实验外科杂志， 1996； 13（3）∶135.
13. 阮祥燕，杜永洪，孔繁斌，等. 高强度聚焦超声定位损伤香猪肝脏组织的病理转归研究 \[J\].中华实验外科杂志，1999； 16（3）∶ 263.
14. Hynynen K, Chung AH, Colucci V, et al. Potential adverse effects of highintensity focused ultrasound exposure on blood vessels in vivo \[J\]. Ultrasound Med Biol, 1996; 22(2)∶193.
15. Prat F, Centarti M, Sibille A, et al. Extracorporeal highintensity focused ultrasound for VX2 liver tumors in the rabbit \[J\]. Hepatology, 1995; 21(3)∶832.
16. 伍烽，王芷龙，张吉吉，等. 高强度聚焦超声治疗剂量与抑制H22肝癌生长效应的关系 \[J\]. 中国超声医学杂志， 1999； 13（6）∶1.
17. Chen L, Haar G, Hill CR, et al. Influence of ablated tissue on the formation of highintensity focused ultrasound lesions \[J\]. Ultrasound Med Biol, 1997; 23(6)∶921.
18. 程树群，周信达，汤钊猷，等. 体外高功率聚焦超声破坏肝组织的实验研究 \[J\]. 华人消化杂志， 1998； 6（3）∶198.
19. Clarke RL, Haar GR. Temperature rise recorded during lesion formation by highintensity focused ultrasound \[J\]. Ultrasound Med Biol, 1997; 23(2)∶299.
20. MassarMoreno R, Dimianou CA, Saughvi NT. Noninvasive temperature estimation in tissue via ultrasound echoshifts. Part Ⅱ: in vitro study \[J\]. J Acoust Am, 1996; 100(4 pt 1)∶2522.
21. Bohris C, Schreber WG, Jenne J, et al. Quantitative MR temperature monitoring of highintensity focused ultrasound therapy \[J\]. Magn Reson Imaging, 1999; 17(4)∶ 603.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

The Application of High Intensity Focused Ultrasound in the Tumor Treatment

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