ObjectiveTo assess the effects of Radix Salviae Miltiorrhizae (RSM) on patency and proliferation lesion of autologous vein to artery grafts in the earlymiddle stage.MethodsAutologous jugular vein was grafted into abdominal artery in the rats. The rats were divided into two groups: RSM group and control group. The rats in RSM group were fed with RSM ［24 g/(kg·d )］,which began 1 day before operation and continued until harvesting. Vein grafts were harvested at 1,3 days, 1, 2, 4 and 8 weeks after surgery for examining the patency, thickness of intimamedia and expression of proliferating cell nuclear antigen (PCNA). ResultsNo significant differences existed in patency of vein grafts between the two groups (P gt;0.05). The intimamedia thickness of the vein grafts in RSM group decreased 1/3 compared with control group at 2, 4 and 8 weeks (P＜0.01). The PCNA positive cells in RSM group reduced significantly as compared to the control group (P＜0.01). ConclusionRSM can inhibit proliferation lesion of vein grafts but has no influence on patency of vein grafts in the earlymiddle stage.
Citation：
MA Xiaogan,SHI De.. Effect of Radix Salviae Miltiorrhizae on Patency and Proliferation Lesion of Autologous Vein to Artery Grafts in the EarlyMiddle Stage. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 232-234. doi:
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| 1. |
Cox JL, Chiasson DA， Gotlieb AI. Stranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries [J]. Prog Cardiovasc Dis, 1991； 34（1）∶45.
|
| 2. |
邹正午，徐理纳，田金英. 迷迭香酸抗血栓和抗血小板聚集作用 [J]. 药学学报，1993； 28（4）∶241.
|
| 3. |
周小明，陆再英，汪道文. 丹参防治实验性动脉再狭窄及其机制的初步研究 [J].中国中西医结合杂志，1996； 16（8）∶480.
|
| 4. |
王关嵩. 血小板源生长因子及其对血管平滑肌细胞作用的研究进展 [J].国外医学临床生物化学与检验学分册，1997； 18(4)∶149.
|
| 5. |
Gryglewski RJ, Chlopicki S，Swies J, et al. Prostacyclin, nitric oxide， and atherosclerosis [J]. Ann N Y Acad Sci, 1995； 748∶ 194.
|
| 6. |
劳杰，顾玉东. 中药对血管内皮细胞缺血缺氧损伤保护作用的实验研究 [J]. 中华手外科杂志，1993； 9（1）∶39.
|
| 7. |
周小明，陆再英. 丹参注射液对培养的动脉平滑肌细胞增殖的影响 [J].中药药理与临床，1995； 11（3）∶31.
|
| 8. |
颅坤平，赵升皓，王道生.钙和钙调素与血管平滑肌细胞增殖 [J].中国药理学与毒理学杂志，1988； 2（3）∶166.
|
- 1. Cox JL, Chiasson DA， Gotlieb AI. Stranger in a strange land: the pathogenesis of saphenous vein graft stenosis with emphasis on structural and functional differences between veins and arteries [J]. Prog Cardiovasc Dis, 1991； 34（1）∶45.
- 2. 邹正午，徐理纳，田金英. 迷迭香酸抗血栓和抗血小板聚集作用 [J]. 药学学报，1993； 28（4）∶241.
- 3. 周小明，陆再英，汪道文. 丹参防治实验性动脉再狭窄及其机制的初步研究 [J].中国中西医结合杂志，1996； 16（8）∶480.
- 4. 王关嵩. 血小板源生长因子及其对血管平滑肌细胞作用的研究进展 [J].国外医学临床生物化学与检验学分册，1997； 18(4)∶149.
- 5. Gryglewski RJ, Chlopicki S，Swies J, et al. Prostacyclin, nitric oxide， and atherosclerosis [J]. Ann N Y Acad Sci, 1995； 748∶ 194.
- 6. 劳杰，顾玉东. 中药对血管内皮细胞缺血缺氧损伤保护作用的实验研究 [J]. 中华手外科杂志，1993； 9（1）∶39.
- 7. 周小明，陆再英. 丹参注射液对培养的动脉平滑肌细胞增殖的影响 [J].中药药理与临床，1995； 11（3）∶31.
- 8. 颅坤平，赵升皓，王道生.钙和钙调素与血管平滑肌细胞增殖 [J].中国药理学与毒理学杂志，1988； 2（3）∶166.
