Large Hepatocarcinoma: Treatment with RadioFrequency Ablation_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Southwest Hepatobiliary Surgery Hospital, The Third Military Medical University, Chongqing 400038;

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Keywords：

Radio frequency ablation; Treatment; Large hepatocarcinoma

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Objective To explore efficacy and safety of radiofrequency ablation (RFA) in the treatment of large hepatocarcinoma. MethodsFortythree cases of large hepatocarcinoma underwent RFA with the expandable cluster electrode,eight of all cases had undergone transcatheter artery chemoembolization (TAE) for 1-2 sessions within 2 months before RFA; the tumors were 5-10 cm in diameter, mean 7.5 cm. Hepatic function examination, alphafetoprotein, enhanced CT scans,color ultrasonography and needle biopsy were performed,pre and posttreatment. Complete necrosis was evaluated by dynamic enhanced CT scans and biopsy. Therapeutic time and sessions of RFA,length of stay in hospital and complications of RFA were observed; and thirtynine of 43 cases after RFA were followed up for 12-18 months.ResultsFortythree cases of large hepatocarcinoma received RFA for 67 sessions， 1-3 sessions per case，mean 1.6 sessions; therapeutic time 55-150 min,mean 75 min; length of stay in hospital 3-15 day， mean 8.7 day; major complications of RFA included local skin burn of electrode board in 2 cases （4.6%） and moderatetolarge right pleural effusion in 3 cases （7.0%），overall complications rate was 11.6%; complete necrosis was achieved in 41.0% of cases which were evaluated by dynamic enhanced CT scans at least 6 months followed RFA; of thirtyone cases of positive AFP, AFP level became negative in 3,decreased obviously in 5 within 6-12 months after RFA; in 12-18 months followup,oneyear survival rate was 69.2%.Conclusion RFA appears to be safe, effective and minor invasive for the treatment of large hepatocarcinoma.

Citation： FAN Linjun,MA Kuansheng,HE Zhengping,et al.. Large Hepatocarcinoma: Treatment with RadioFrequency Ablation. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(4): 265-268. doi: Copy

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1. Dodd GD 3rd, Soulen MC, Kane RA，et al. Minimally invasive treatment of malignant hepatic tumors: at the threshold of a major breakthrough [J]. Radiographics, 2000； 20(1)∶9.
2. 黄志强主编.现代腹部外科学 [M].第1版.长沙: 湖南科学技术出版社，1995∶249~271.
3. Livraghi T, Goldberg SN, Lazzaroni S, et al. Hepatocellular carcinoma: radiofrequency ablation of medium and large lesions [J]. Radiology, 2000; 214(3)∶761.
4. Livraghi T, Goldberg SN, Lazzaroni S,et al. Small hepatocellular carcinoma: treatment with radiofrequency ablation versus ethanol injection [J]. Radiology, 1999; 210(3)∶655.
5. Buscarini L, Buscarini E, Di Stasi M,et al. Percutaneous radiofrequency thermal ablation combined with transcatheter arterial embolization in the treatment of large hepatocellular carcinoma [J].Ultraschall Med,1999; 20(2)∶47.
6. Seegenschmiedt MH, Brady LW, Sauer R. Interstitial thermoradiotherapy: review on technical and clinical aspects [J].Am J Clin Oncol,1990; 13(4)∶352.
7. Rossi S, Garbagnati F, De Francesco I, et al. Relationship between the shape and size of radiofrequency induced thermal lesions and hepatic vascularization [J]. Tumori,1999; 85(2)∶128.
8. 徐辉雄，张青萍. 超声引导下肝脏肿瘤的射频消融治疗 [J].中华超声影像学杂志,2000； 9（4）∶255.
9. Seki T, Tamai T, Nakagawa T,et al. Percutaneous radiofrequency (RF) ablation therapy for hepatocellular carcinoma: difficulty in removing the expandable RF needle electrode [J].AJR Am J Roentgenol,2000; 174(1)∶264.
10. Farmer DG, Rosove MH, Shaked A, et al. Current treatment modalities for hepatocellular carcinoma [J]. Ann Surg,1994; 219(3)∶236.
11. Goldberg SN, Gazelle GS, Mueller PR. Thermal ablation therapy for focal malignmancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance [J]. AJR Am J Roentgenol, 2000; 174(2)∶323.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Large Hepatocarcinoma: Treatment with RadioFrequency Ablation

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