Expression of Collagen Ⅳ in Breast Cancer and Its’ Clinical Significance_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Xiaodong , YANG Jinqiao.

Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041;

Corresponding author：

Keywords：

Breast cancer Collagen Ⅳ Basilar membrane Invasion Metastasis

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ObjectiveTo explore the expression of collagen Ⅳ in breast cancer and its clinical significance. We analyzed the correlation of the results with other prognostic parameters which included tumor size, status of estrogen receptor, axillary nodal status, TNM grade, and 5 years survival. The expression of collagen Ⅳ in 93 cases of human primary breast cancer as well as 5 cases of benign breast masses were examined.MethodsUsing monoclonal antibodies of collagen Ⅳ, the expression of collagen Ⅳ in breast masses were detected with immunohistochemical technique (LSAB).ResultsThe absent expression of collagen Ⅳ in the tumor masses was correlated with axillary lymph node involvement, tumor size and poor prognosis (5 years survival). The patients who had no expression of collagen Ⅳ in tumor masses had a shorter survival. ConclusionThe expression of collagen Ⅳ in tumor samples are correlated with axillary node involvement and prognosis. Collagen Ⅳ would be helpful for evaluation of invasion and treatment in breast carcinoma.

Citation： WANG Xiaodong,YANG Jinqiao.. Expression of Collagen Ⅳ in Breast Cancer and Its’ Clinical Significance. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 303-305. doi: Copy

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1. Fridman R, Alon Y, Doljanski F, et al. Cell interaction with the extracellular matrices produced by endothelial and fibroblasts [J]. Exp Cell Res, 1985; 158(2)∶461.
2. Aznavoorian S, Murphy AM, StellerStevenson WG, et al. Molecular aspects of tumor cell invasion and metastasis [J]. Cancer, 1993; 71(4)∶1368.
3. Sobin LH, Wittekind C. TNM classification of malignant tumors [M]. 5th ed. New York: Gohn Wiley and Sons Inc, 1997∶123-167.
4. Campo E, Merino MJ, Tavassoli FA, et al. Evaluation of basement membrane components and the 72 kDa type Ⅳ Collagenase in serous tumors of the ovary [J]. Am J Surg Pathol, 1992; 16(5)∶500.
5. Birembaut P, Caron Y, Adnet JJ, et al. Usefulness of basement membrane markers in tumoural pathology [J]. J Pathol, 1985; 145(4)∶283.
6. Mahfouz SM, Chevallier M, Grimaud JA. Distribution of the major connective matrix components of the stromal reaction in breast carcinoma. An immunohistochemical study [J]. Cell Mol Biol, 1987; 33(4)∶453.
7. Albrechtsen R, Nielsen M, Wewer U, et al. Basement membrane changes in breast cancer detected by immunohistochemical staining for laminin [J]. Cancer Res, 1981; 41(12 Pt 1)∶5076.
8. Barsky SH, Rao CN, Grotendorst GR, et al. Increased content of type Ⅴ collagen in desmoplasia of human breast carcinoma [J]. Am J Path, 1981; 108（3）∶279.
9. Clavel C, Doco M, Lallemand A, et al. Detection by in situ hybridization of messenger RNAs of collagen type I and Ⅳ in murine mammary [J]. Int J Cancer, 1989; 44(3)∶548.
10. Liotta LA. Tumor invasion and metastasis: role of the basement membrane. WarnerLambert ParkeDavis Award lecture [J]. Am J Pathol, 1984; 117(3)∶339.
11. Liotta LA, StetlarStevenson W. Metalloproteinase and malignant conversion: does correlation imply causality? [J]. J Natl Cancer Inst, 1989; 81(8)∶556.
12. 刘刚，韩德昌，严全梅. 口腔鳞癌Ⅳ型胶原和层粘连蛋白的表达与颈淋巴结转移的关系 [J]. 临床口腔医学杂志，2000； 16（2）∶74.
13. 张健康，李晓丽，李亮成，等. Ⅳ型胶原、层粘连蛋白、纤维粘连蛋白在胃癌中表达的意义 [J]. 山西医科大学学报，2000； 31（2）∶114.
14. 宝建中，郑建明，周霖，等. 癌基因蛋白p21、p185、EGFR及LN、Ⅳ型胶原在骨肉瘤中的表达 [J]. 肿瘤防治研究，1999； 26（4）∶265.
15. Reed JA, Loganzo F Jr, Shea CR, et al. Loss of expression of the p16/cyclindependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression [J]. Cancer Res, 1995; 55(13)∶2713.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Expression of Collagen Ⅳ in Breast Cancer and Its’ Clinical Significance

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