Relationship Between cmet, p53 Expression in Breast Carcinoma and Tumor Angiogenesis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, The Fourth Affiliated Hospital of Dalian Medical University, Dalian 116001;

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Tumor angiogenesis c-met proteinp 53 protein Breast carcinoma

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ObjectiveTo find the role of oncogene cmet and suppressor gene p53 in the process of tumor angiogenesis and their clinical significance. MethodsBy immunohistochemical method and computer image analysis technique, microvessel count and cmet, p53 protein expression were quantitatively determined in 80 cases of breast carcinoma and 20 cases of breast fibroadenoma. ResultsThe high microvessel count and the positive expression of cmet, p53 were significantly correlated with histologic grade, lymph node metastasis and the stage of the tumor (P＜0.01). The high microvessel count was significantly correlated with the positive expression of cmet and p53 (P＜0.01).ConclusionBoth oncogene cmet and suppressor gene p53 modulate tumor angiogenesis of breast carcinoma.

Citation： YIN Jiajun,SONG Yan,WANG Xiaobo,et al.. Relationship Between cmet, p53 Expression in Breast Carcinoma and Tumor Angiogenesis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 316-318. doi: Copy

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1. Bosari S, Lee AK, DeLellis RA, et al. Microvessel quantitation and prognosis in invasive breast carcinoma [J]. Hum Pathol, 1992; 23(7)∶755.
2. Weidner N, Folkman J, Pozza F, et al . Tumor angiogenesis: a new significant and independent prognostic indicator in earlystage breast carcinoma [J]. J Natl Cancer Inst, 1992; 84(24)∶1875.
3. Jin L, Fuchs A, Schnitt SJ, et al. Expression of scatter factor and cmet receptor in benign and malignant breast tissue [J]. Cancer, 1997; 79(4)∶749.
4. Hollstein M, Sidransky K, Vogelstein B, et al. p53 mutations in human cancers [J]. Science, 1991; 253(5015)∶49.
5. Levine AJ, Perry ME, Chang A, et al. The 1993 Walter Hubert Lecture: the role of the p53 tumoursuppressor gene in tumorigenesis [J]. Br J Cancer, 1994; 69(3)∶409.
6. Grant DS, Kleinman HK, Goldberg ID, et al. Scatter factor induces blood vessel formation in vivo [J].Proc Natl Acad Sci U S A, 1993; 90(5)∶1937.
7. Xu M, Kumar D, Srinivas S, et al. Parenteral gene therapy with p53 inhibits human breast tumors in vivo through a bystander mechanism without evidence of toxicity [J]. Hum Gene Ther, 1997; 8(2)∶177.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Relationship Between cmet, p53 Expression in Breast Carcinoma and Tumor Angiogenesis

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