Effect of Polymorphonuclear Neutrophils on Liver Damage in Acute Pancreatitis_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, Chengdu General Hospital of PLA, Chengdu 610083;

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Acute pancreatitis Polymorphonuclear neutrophil Liver damage

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ObjectiveTo evaluate the effect of polymorphonuclear neutrophils (PMN) on liver damage in acute pancreatitis. MethodsSeventytwo wistar rats were randomly divided into acute pancreatitis (AP) group, acute pancreatitis with PMN depleted (APD) group and sham operation (SO) group. Liver damage was assessed by histological changes and the level of alanine aminotransferase (ALT) in serum. The number of PMN infiltration in liver was reflected by myeloperoxidase (MPO). ResultsMPO significantly increased from 6 to 24 hours in AP and APD groups. However, the level of MPO was significantly higher in AP group than that in APD group. ALT significantly increased from 3 to 24 hours in these two groups, but the level of ALT was significantly lower in APD group than that in AP group. Meanwhile, the hepatic pathological changes were more severe in AP group than that in APD group. ConclusionPMN play an important role in liver damage during acute pancreatitis.

Citation： SHI Li,TIAN Fuzhou,HUANG Darong,et al.. Effect of Polymorphonuclear Neutrophils on Liver Damage in Acute Pancreatitis. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 332-334. doi: Copy

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1. 董荣春，闵新歌，金海,等.急性胰腺炎致猝死31例病理形态学分析 [J]. 第二军医大学学报，1990; 11(5)∶413.
2. 罗武生，郭兆贵.用髓过氧化物酶法测定心肌组织中的中性白细胞 [J]. 中国药理学通报，1990； 6（4）∶264.
3. 黄显凯，韩本立. 急性胆管炎多形核白细胞聚集及其肝损害作用的研究 [J]. 中国普外基础与临床杂志, 1999； 6(3)∶146.
4. 王晓军,罗向东, 罗勤,等. 严重烧伤早期粘附分子的表达对中性粒细胞在肝脏中聚集的影响 [J]. 中华整形烧伤外科杂志, 1998； 14(4)∶258.
5. Provost P, Borgeat P, Merhi Y. Platelets, neutrophils, and vasoconstriction after arterial injury by angioplasty in pigs: effects of MK886, a leukotriene biosynthesis inhibitor [J].Br J Pharmacol, 1998； 123(2)∶251.
6. Dabrowski A, Gabryelewicz A, Chyczewski L. The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress [J]. Int J Pancreatol, 1995； 17(2)∶173.
7. Weichert W, Bredin HK. A PAFacether antagonist(N 4870 RP/Rhonepoulenc) and laserinduced thrombin in rat mesenteric vessels [J]. Haemostasis, 1989； 19(4)∶229.
8. Selak MA, Smith JB. Plateletactivating factorinduced calcium mobilization in human platelets and neutrophils: effects of PAFacether antagonist [J]. J Lipid Mediat, 1989； 1(2)∶125.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Effect of Polymorphonuclear Neutrophils on Liver Damage in Acute Pancreatitis

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