Clinical Significance of Angiogenesis in Primary Gallbladder Carcinoma_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Yijun ¹ , LIU Jianmin ² , SHI Jingsen. ¹

Lab of Hepatobiliary Surgery, The First Hospital of Xi’an Jiaotong University, Xi’an 710061;

Corresponding author：

Keywords：

Primary gallbladder carcinoma Angiogenesis Progress Prognosis

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ObjectiveTo discuss the relationship between angiogenesis and the clinical pathological characteristics, prognosis in primary gallbladder carcinoma (PGC ). MethodsThe specimens of 42 patients with PGC who underwent operation during 1993 and 1996 were collected. The immunohistochemical staining was performed in these specimens through SABC manner. Angiogenesis was represented by intratumor microvessel count (MVC ) and expression of vascular endothelial growth factor (VEGF ).ResultsIn all the patients, the average MVC was 70.4±20.7, and the VEGF positive expression rate was 69.0%. The mean MVC was 57.9±15.4 in the tumor of histograde Ⅰ and Ⅱ, and was 88.8±11.5 in another group of grade Ⅲ and Ⅳ respectively. The mean MVC was 45.0±17.0 in the cases of Nevin stage Ⅰ, Ⅱ and Ⅲ, and was 77.2±16.0 in the other cases of Nevin stage Ⅳ and Ⅴ. There were significant differences between two groups. VEGF expression positive rate was correlated with grade and stage, in the patients with poordifferentiated grade and late stage the MVC was significant higher. The expression of VEGF was markedly correlated with MVC. The 3year survival rate was significant lower in the group of high MVC or VEGF positive expression. Conclusion Manifold VEGF secretion in PGC may increase the MVC value, and accelerate the tumor advance and metastasis. Angiogenesis may be considered as an effective predictor to the prognosis of the primary gallbladder carcinoma.

Citation： YANG Yijun,LIU Jianmin,SHI Jingsen.. Clinical Significance of Angiogenesis in Primary Gallbladder Carcinoma. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 345-347. doi: Copy

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3. Pavlopoulos PM，Konstantinidou AE，Agapitos E，et al. A morphometric study of neovascularization in colorectal carcinoma [J]. Cancer， 1998； 83（10）∶2067.
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CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Clinical Significance of Angiogenesis in Primary Gallbladder Carcinoma

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