ObjectiveTo study the role of survivin gene in the research work of tumor. MethodsLiteratures about the molecular structure, function, mechanism,distribution of survivin gene and its role in the treatment of tumor were reviewed.ResultsSurvivin was a new member of inhibitor of apoptosis protein family, expressed in almost all the human tumors independent to the expression of bcl2. The expression of survivin was significantly correlated with the poor prognosis of tumor patients. Survivin inhibited the apoptosis of tumor cells via inhibiting the activity of caspase3, the effector molecule of the apoptosis signal transduction pathway. Inhibition of the expression of survivin gene could block its effect of inhibiting apoptosis and consequently get a therapeutic effect of tumors.ConclusionSurvivin is commonly expressed in human tumor tissues. It can be identified as an important prognostic parameter of poor outcome and a new therapeutic target in cancer.
Citation： CHEN Tao,TIAN Fuzhou.. Development of Survivin Gene and Tumor Research. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(5): 364-366. doi: Copy
| 1. | Adida C, Crotty PL, McGrath J, et al. Developmentally regulated expression of the novel cancer antiapoptosis gene survivin in human and mouse proliferation [J]. Am J Pathol,1998； 152(1)∶43. |
| 2. | Konno R, Yamakawa H, Utsunomiya H, et al. Expression of survivin and bcl2 in the normal human endometrium [J]. Mol Hum Reprod,2000； 6(6)∶529. |
| 3. | Uren AG, Beilharz T, O’connell MJ, et al. Role for yeast inhibitor of apoptosis (IAP)like proteins in cell division [J]. Proc Natl Acad Sci USA, 1999； 96(18)∶10170. |
| 4. | Fraser AG, James C, Evan GI, et al. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR1 plays a conserved role in cytokinesis [J]. Curr Biol, 1999； 9(6)∶292. |
| 5. | Takahashi R, Deveraux Q, Tamm I, et al. A single BIR domain of XIAP sufficient for inhibiting caspases [J]. J Biol Chem, 1998； 273(14)∶7787. |
| 6. | Li F, Altieri DC. The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycledependent expression [J]. Cancer Res, 1999； 59(13)∶3143. |
| 7. | Conway EM, Pollefeyt S, Cornelissen J, et al. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions [J]. Blood, 2000； 95(4)∶1435. |
| 8. | Kobayashi K, Hatano M, Otaki M, et al. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation [J]. Proc Natl Acad Sci USA, 1999； 96(4)∶1457. |
| 9. | Ambrosini G, Adida C, Altieri DC, et al. A novel antiapoptosis gene, survivin expressed in cancer and lymphoma [J]. Nat Med, 1997； 3(8)∶917. |
| 10. | Verdecia MA, Huang H, Dutil E, et al. Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement [J]. Nat Struct Biol,2000； 7(7)∶602. |
| 11. | Mahotka C, Wenzel M, Springer E, et al. survivindeltaEx3 and survivin2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties [J]. Cancer Res, 1999； 59(24)∶6097. |
| 12. | Tamm I, Wang Y, Sausville E, et al. IAPfamily protein survivin inhibits caspase activity and apoptosis induced by Fas(CD95), Bax, caspases, and anticancer drugs [J]. Cancer Res, 1998； 58(23)∶5315. |
| 13. | Suzuki A, Ito T, Kawano H, et al. Survivin initiates procaspase3/p21 complex formation as a result of interaction with CDK4to resist Fasmediated cell death [J]. Oncogene, 2000； 19(10)∶1346. |
| 14. | Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with CDK4/p16(INK4a) and CDK2/cyclin E complex activation [J]. Oncogene, 2000； 19(29)∶3225. |
| 15. | Li F, Ambrosini G, Chu EY, et al. Control of apoptosis and mitotic spindle checkpoint by survivin [J]. Nature, 1998； 396(6711)∶580. |
| 16. | Ito T, Shiraki K, Sugimoto K, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma [J]. Hepatology, 2000； 31(5)∶1080. |
| 17. | Sarela AI, Macadam RC, Farmery SM, et al. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma [J]. Gut, 2000； 46(5)∶645. |
| 18. | Kawasaki H, Altieri DC, Lu CD, et al. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer [J]. Cancer Res, 1998； 58(22)∶5071. |
| 19. | Tanaka K, Iwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas [J]. Clin Cancer Res, 2000； 6(1)∶127. |
| 20. | Monzo M, Roseu R, Felip E, et al. A novel antiapoptosis gene:Reexpression of survivin messenger RNA as a prognosis marker in nonsmallcell lung cancer [J]. J Clin Oncol, 1999； 17(7)∶2100. |
| 21. | Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas [J]. Cancer Res, 1998； 58(9)∶1808. |
| 22. | Saitoh Y, Yaginuma Y, Ishikawa M. Analysis of bcl2, Bax and survivin genes in uterine cancer [J]. Int J Oncol, 1999； 15(1)∶137. |
| 23. | Islam A, Kageyama H, Takada N, et al. High expression of survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma [J]. Oncogene, 2000； 19(5)∶617. |
| 24. | Grossman D, McNiff JM, Li F, et al. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line [J]. Lab Invest, 1999； 79(9)∶1121. |
| 25. | Swana HS, Grossman D, Anthony JN, et al. Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer [J]. N Engl J Med, 1999； 341(6)∶452. |
| 26. | Tran J, Rak J, Sheehan C, et al. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells [J]. Biochem Biophys Res Commun, 1999； 264(3)∶781. |
| 27. | Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem, 2000； 275(13)∶9102. |
| 28. | O’connor DS, Schechner JS, Adida C. Control of apoptosis during angiogenesis by survivin expression in endothelial cells [J]. Am J Pathol, 2000； 156(2)∶393. |
| 29. | Buolamwini JK. Novel anticancer drug discovery [J]. Curr Opin Chem Biol, 1999； 3(4)∶500. |
| 30. | Olie RA, SimoesWust AP, Baumann B, et al. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy [J]. Cancer Res, 2000； 60(11)∶2805. |
| 31. | Chen J, Wu W, Tahir SK, et al. Downregulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorageindependent growth [J]. Neoplasia, 2000； 2(3)∶235. |
| 32. | Ambrosini G, Adida C, Sirugo G, et al. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting [J]. J Biol Chem, 1998； 273(18)∶11177. |
- 1. Adida C, Crotty PL, McGrath J, et al. Developmentally regulated expression of the novel cancer antiapoptosis gene survivin in human and mouse proliferation [J]. Am J Pathol,1998； 152(1)∶43.
- 2. Konno R, Yamakawa H, Utsunomiya H, et al. Expression of survivin and bcl2 in the normal human endometrium [J]. Mol Hum Reprod,2000； 6(6)∶529.
- 3. Uren AG, Beilharz T, O’connell MJ, et al. Role for yeast inhibitor of apoptosis (IAP)like proteins in cell division [J]. Proc Natl Acad Sci USA, 1999； 96(18)∶10170.
- 4. Fraser AG, James C, Evan GI, et al. Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR1 plays a conserved role in cytokinesis [J]. Curr Biol, 1999； 9(6)∶292.
- 5. Takahashi R, Deveraux Q, Tamm I, et al. A single BIR domain of XIAP sufficient for inhibiting caspases [J]. J Biol Chem, 1998； 273(14)∶7787.
- 6. Li F, Altieri DC. The cancer antiapoptosis mouse survivin gene: characterization of locus and transcriptional requirements of basal and cell cycledependent expression [J]. Cancer Res, 1999； 59(13)∶3143.
- 7. Conway EM, Pollefeyt S, Cornelissen J, et al. Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions [J]. Blood, 2000； 95(4)∶1435.
- 8. Kobayashi K, Hatano M, Otaki M, et al. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation [J]. Proc Natl Acad Sci USA, 1999； 96(4)∶1457.
- 9. Ambrosini G, Adida C, Altieri DC, et al. A novel antiapoptosis gene, survivin expressed in cancer and lymphoma [J]. Nat Med, 1997； 3(8)∶917.
- 10. Verdecia MA, Huang H, Dutil E, et al. Structure of the human antiapoptotic protein survivin reveals a dimeric arrangement [J]. Nat Struct Biol,2000； 7(7)∶602.
- 11. Mahotka C, Wenzel M, Springer E, et al. survivindeltaEx3 and survivin2B: two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties [J]. Cancer Res, 1999； 59(24)∶6097.
- 12. Tamm I, Wang Y, Sausville E, et al. IAPfamily protein survivin inhibits caspase activity and apoptosis induced by Fas(CD95), Bax, caspases, and anticancer drugs [J]. Cancer Res, 1998； 58(23)∶5315.
- 13. Suzuki A, Ito T, Kawano H, et al. Survivin initiates procaspase3/p21 complex formation as a result of interaction with CDK4to resist Fasmediated cell death [J]. Oncogene, 2000； 19(10)∶1346.
- 14. Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with CDK4/p16(INK4a) and CDK2/cyclin E complex activation [J]. Oncogene, 2000； 19(29)∶3225.
- 15. Li F, Ambrosini G, Chu EY, et al. Control of apoptosis and mitotic spindle checkpoint by survivin [J]. Nature, 1998； 396(6711)∶580.
- 16. Ito T, Shiraki K, Sugimoto K, et al. Survivin promotes cell proliferation in human hepatocellular carcinoma [J]. Hepatology, 2000； 31(5)∶1080.
- 17. Sarela AI, Macadam RC, Farmery SM, et al. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma [J]. Gut, 2000； 46(5)∶645.
- 18. Kawasaki H, Altieri DC, Lu CD, et al. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer [J]. Cancer Res, 1998； 58(22)∶5071.
- 19. Tanaka K, Iwamoto S, Gon G, et al. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas [J]. Clin Cancer Res, 2000； 6(1)∶127.
- 20. Monzo M, Roseu R, Felip E, et al. A novel antiapoptosis gene:Reexpression of survivin messenger RNA as a prognosis marker in nonsmallcell lung cancer [J]. J Clin Oncol, 1999； 17(7)∶2100.
- 21. Lu CD, Altieri DC, Tanigawa N. Expression of a novel antiapoptosis gene, survivin, correlated with tumor cell apoptosis and p53 accumulation in gastric carcinomas [J]. Cancer Res, 1998； 58(9)∶1808.
- 22. Saitoh Y, Yaginuma Y, Ishikawa M. Analysis of bcl2, Bax and survivin genes in uterine cancer [J]. Int J Oncol, 1999； 15(1)∶137.
- 23. Islam A, Kageyama H, Takada N, et al. High expression of survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma [J]. Oncogene, 2000； 19(5)∶617.
- 24. Grossman D, McNiff JM, Li F, et al. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line [J]. Lab Invest, 1999； 79(9)∶1121.
- 25. Swana HS, Grossman D, Anthony JN, et al. Tumor content of the antiapoptosis molecule survivin and recurrence of bladder cancer [J]. N Engl J Med, 1999； 341(6)∶452.
- 26. Tran J, Rak J, Sheehan C, et al. Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells [J]. Biochem Biophys Res Commun, 1999； 264(3)∶781.
- 27. Papapetropoulos A, Fulton D, Mahboubi K, et al. Angiopoietin1 inhibits endothelial cell apoptosis via the Akt/survivin pathway [J]. J Biol Chem, 2000； 275(13)∶9102.
- 28. O’connor DS, Schechner JS, Adida C. Control of apoptosis during angiogenesis by survivin expression in endothelial cells [J]. Am J Pathol, 2000； 156(2)∶393.
- 29. Buolamwini JK. Novel anticancer drug discovery [J]. Curr Opin Chem Biol, 1999； 3(4)∶500.
- 30. Olie RA, SimoesWust AP, Baumann B, et al. A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy [J]. Cancer Res, 2000； 60(11)∶2805.
- 31. Chen J, Wu W, Tahir SK, et al. Downregulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorageindependent growth [J]. Neoplasia, 2000； 2(3)∶235.
- 32. Ambrosini G, Adida C, Sirugo G, et al. Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting [J]. J Biol Chem, 1998； 273(18)∶11177.