BIOTHERAPY FOR PANCREATIC CANCER： CURRENT AND PROSPECTIVE STRATEGIES_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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赵玉沛 , 戴梦华

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胰腺癌生物治疗

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近年来，对胰腺癌虽然在诊断技术和治疗手段上有了长足的进步，但胰腺癌患者的生存时间并没有延长。常规的治疗手段中，手术仍是达到治愈的唯一手段，但85%的患者在确诊时癌肿已转移或侵袭到胰外器官而无法切除；放疗和化疗对其尚缺乏确切的疗效。因此，寻求新的、有效的治疗方法是基础研究者和临床医生共同努力的方向。随着肿瘤免疫学和分子生物学研究的进展及人类基因组计划的完成，人们已经对肿瘤的发生、发展和转移机理有了一定的了解。与此同时，基础研究的成果也大大推动了临床研究的进程。20世纪在肿瘤的生物治疗方面取得了不少进展，主要集中在基因治疗、免疫毒素、肿瘤疫苗和细胞因子等方面。

Citation： 赵玉沛,戴梦华. BIOTHERAPY FOR PANCREATIC CANCER： CURRENT AND PROSPECTIVE STRATEGIES. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2002, 9(6): 371-373. doi: Copy

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10.	Kimura M, Yoshida Y, Narita M, et al. Acquired immunity in nude mice induced by expression of the IL2 or IL4 gene in human pancreatic carcinoma cells and antitumor effect generated by in vivo gene transfer using retrovirus [J]. Int J Cancer, 1999; 82(4)∶ 549.
11.	Yoshida Y, Tasaki K, Kimurai M, et al. Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells [J]. Anticancer Res, 1998; 18(1A)∶333.
12.	AbdelWahab M, E1Shennawy F, Agha S, et al. Evaluation of cell mediated immunity in advanced pancreatic carcinoma before and after treatment with interleukin2(IL2) [J]. Hepatogastroenterology, 1999; 46（Suppl 1）∶1293.
13.	Ogawa T, Kusumoto M, Mizumoto K, et al. GMCSF gene therapy using adsenoviral vector in hamster pancreatic cancer [J]. J Hepatobiliary Pancreat Surg, 2000; 7(3)∶ 306.

1. Schreiber M, Muller WJ, Singh G, et al. Comparision of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4a, p18INK4C, p19INK4D,p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity [J]. Oncogene, 1999; 18(9)∶1663.
2. Chintala SK,Fueyo J, GomezManzano C, et al. Adenovirusmediated p16/CDKN2 gene transfer suppresses glioma invasion in vitro [J]. Oncogene, 1997; 15(17)∶ 2049.
3. Fujimoto K, Hosotani R, Miyamoto Y, et al. Inhibition of pRb phosphorylation and cell cycle progression by an antennapediap16(INK4A) fusion peptide in pancreatic cancer cells [J]. Cancer Lett, 2000;　159(2)∶151.
4. Ghaneh P, Greenhalf W, Humpreys M, et al. Adenovirusmediated transfer of p53 and p16INK4a results in pancreatic cancer regression in vitro and in vivo [J]. Gene Ther, 2001; 8(3)∶199.
5. Bouvet M, Bold RJ, Lee J, et al. Adenovirusmediated wildtype p53 tumor suppresser gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [J]. Ann Surg Onco, 1998; 5(8)∶ 681.
6. Fujiwara T, Grimm EA, Mukhopadhyay T, et al. Induction of chemosensitivity in human lung cancer cells in vivo by adenovirusmediated transfer of the wildtype p53 gene [J]. Cancer Res, 1994; 54(9)∶2287.
7. Yang L, Hwang R, Pandit L, et al. Gene therapy of metastatic pancreas cancer with intraperitoneal injections of concentrated retroviral herpes simplex thymidine kinase vector supernatant and ganciclovir [J]. Ann Surg, 1996; 224(3)∶405.
8. Alpaugh RK, Schultz J, McAleer C, et al. Superantigentargeted therapy: phase Ⅰ escalating repeat dose trial of the fusion protein PNU214565 in patients with advanced gastrointestinal malignancies [J]. Clin Cancer Res, 1998; 4(8)∶1903.
9. Schmiegel W, Schmielau J, HenneBruns D, et al. Cytokinemediated enhancement of epidermal growth factor receptor expression provides an immunological approach to the therapy of pancreatic cancer [J]. Proc Natl Acad Sci USA, 1997; 94(23)∶12622.
10. Kimura M, Yoshida Y, Narita M, et al. Acquired immunity in nude mice induced by expression of the IL2 or IL4 gene in human pancreatic carcinoma cells and antitumor effect generated by in vivo gene transfer using retrovirus [J]. Int J Cancer, 1999; 82(4)∶ 549.
11. Yoshida Y, Tasaki K, Kimurai M, et al. Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells [J]. Anticancer Res, 1998; 18(1A)∶333.
12. AbdelWahab M, E1Shennawy F, Agha S, et al. Evaluation of cell mediated immunity in advanced pancreatic carcinoma before and after treatment with interleukin2(IL2) [J]. Hepatogastroenterology, 1999; 46（Suppl 1）∶1293.
13. Ogawa T, Kusumoto M, Mizumoto K, et al. GMCSF gene therapy using adsenoviral vector in hamster pancreatic cancer [J]. J Hepatobiliary Pancreat Surg, 2000; 7(3)∶ 306.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

BIOTHERAPY FOR PANCREATIC CANCER： CURRENT AND PROSPECTIVE STRATEGIES

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