Objective To study the relationship between gastrin and c-myc, c-fos expression in colorectal cancerous tissue and the mechanism of gastrin effect on colorectal cancer.
Methods The gastrin and c-myc, c-fos expression in 48 cases of colorectal cancerous tissue and canceradjacent mucosa were detected with immunohistochemistry techniques.
Results The positive rate of gastrin in colorectal cancerous tissue was 39.58%. The rate of the well differentiated adenocarcinoma was higher than that of the poorly differentiated and mucinous adenocarcinoma(P＜0.05). The positive rates of c-myc and c-fos in colorectal cancerous tissue were higher than those in canceradjacent and normal mucosa. The positive rate of c-myc and c-fos in the group with gastrin positive expression were 78.94% and 73.68%, higher than those in the group with negative gastrin expression(37.93% and 31.04%). Conclusion Some of colorectal cancer cells formed and secreted gastrin through autocrine. The increase of cmyc, c-fos etc oncogene expression probably stimulate the cancer cells proliferation.
Citation：
HE Yujun,HE Shuangwu,FU Tao.. THE RELATIONSHIP BETWEEN GASTRIN AND c-myc， c-fos EXPRESSION IN COLORECTAL CANCEROUS TISSUE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(1): 15-17. doi:
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Copyright © the editorial department of CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY of West China Medical Publisher. All rights reserved
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- 1. Baldwin GS. The role of gastrin and cholecystokinin in normal and neoplastic gastrointestional growth [J]. J Gastroenterol Hepatol, 1995; 10(2)∶215.
- 2. 周廷冲，马贤凯，唐佩眩等.多肽生长因子基础与临床 [M].第1版.北京：中国科学技术出版社，1992∶17～25.
- 3. Finley GG, Koski RA, Melhem MF, et al. Expression of the gastrin gene in the normal human colon and colorectal adenocarcinoma [J]. Cancer Res, 1993; 53(12)∶2919.
- 4. Singh P, Owlia A, Varro A, et al. Gastrin gene expression is required for proliferation and tumorigenicity of human colon cancer cells [J]. Cancer Res, 1996; 56(18)∶4111.
- 5. Williams GT, Smith CA. Molecular regulation of apotosis:genetic controls on cell death [J]. Cell, 1993; 74(5)∶777.
- 6. Chin R, Boyle WY, Meek J, et al. The cfos protein interacts with cjun/Ap1 to stimulate transcription of ABL responsive genes [J]. Cell, 1988; 54(4)∶541.
- 7. Kazuyoshi Y, Toshio S, Masaru T, et al. Establishment and characterization of human signet ring cell gastric carcinoma cell lines with amplification of the cmyc oncogene [J]. Cancer Res, 1991; 51(1)∶381.
- 8. Wang JY, Wang H, Johnson LR. Gastrin stimulates expression of protooncogene cmyc throuth a process involving ployanines in IEC6 cells [J]， Am J Physiol. 1995; 269(cell physiol.38)∶c1474.
- 9. Andrea T, Yoshiaki T, Catherine S, et al. Gastrin and glycineextended progastrin processing intermediates induce different programs of early gene activation [J].J Biol Chem,1995; 270(47)∶28337.
