THE CLINICAL SIGNIFICANCE OF DETECTING THE TELOMERASE ACTIVITY IN COLORECTAL CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

LUO Chengyu ¹ , ZHAO Danning ² , LI Shiyong ¹ , et al. ³

Beijing Army General Hospital, Beijing 100700;

Corresponding author：

Keywords：

Colorectal neoplasm Neoplasm differentiation Telomerase

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Objective To explore the values of telomerase in the diagnosis, therapy and prognostic parameter of colorectal cancer.
Methods Telomerase activity in colorectal cancer, peri-cancerous and normal mucosa was detected by PCRTRAP-ELISA assay.
Results The positive rates of telomerase in colorectal cancer, peri-cancerous and normal mucosa were 84.8%, 20.0% and 0% respectively. 66.7% of the early stage colorectal cancer expressed telomerase. Telomerase activity was reversely correlated with tumor differentiation.
Conclusion Telomerase may be an earlier event of malignant progression in colorectal cancer. It might be a parameter for diagnosis of colorectal cancer.

Citation： LUO Chengyu,ZHAO Danning,LI Shiyong,et al.. THE CLINICAL SIGNIFICANCE OF DETECTING THE TELOMERASE ACTIVITY IN COLORECTAL CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(1): 18-20. doi: Copy

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1. Hoos A, Heep HH, Kaul S, et al. Telomerase activity correlates with tumour aggressiveness and reflects therapy effect in breast cancer [J]. Int J Cancer, 1998; 79(1)∶8.
2. Fang DC, Yong J, Luo YH, et al. Detection of temolerase activity in biopsy samples of colorectal cancer [J]. J Gastroenterol Hepatol, 1999; 14(4)∶328.
3. Kim NW, Pieatyszek MA, Prowse KR, et al. Specific association of human telomerase activity with immortal cells and cancer [J]. Science, 1994; 266(5232)∶2011.
4. Fujita M, Tomita S, Fukui H, et al. Semiquantitative procedure for telomeric repeat amplification protocol(TRAP) assay in colorectal carcinomas [J]. J Exp Clin Cancer Res, 1999; 18(1)∶119.
5. Shay JW, Wright WE. The reactivation of telomerase activity in cancer progression [J]. Trends Genet, 1996; 12(1)∶129.
6. Albanell J, Han W, Mellado B, et al. Telomerase activity is repressed during differentiation of maturationsensitive but not resistant human tumor cell lines [J]. Cancer Res, 1996; 56(7)∶1503.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE CLINICAL SIGNIFICANCE OF DETECTING THE TELOMERASE ACTIVITY IN COLORECTAL CANCER

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