ZHU Zhidong , PU Yongdong.
  • Department of General Surgery, 309th Hospital of P.L.A., Beijing 100091;
5-Fluorouracil Pharmacokinetics Gastric carcinoma Intra-arterial infusion chemotherapy
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Objective  To evaluate the legitimate of regional artery infusion chemotherapy in the treatment of gastric carcinoma.
Methods The pharmacokinetics of 5-Fu after different route of administration was studied.
Results  High concentration of 5-Fu found in portal vein via left-gastric intra-artetial administration were 4-40 folds higher than the group via intravenous administration.The time of high concentrations of 5-Fu via left-gastric intra-arterial administration maintained significantly longer than by intravenous administraion. The concentration of 5-Fu in tumor tissues and paratumorous lymph tissues by intra-arterial administration were 19 times and 23 times of the group by intravenous administration.
Conclusion  Regional arterial infusion chemotherapy can significantly increase the concentration of chemotherapeutic drugs in the tumorous region.

Citation： ZHU Zhidong,PU Yongdong.. THE STUDY OF PHARMACOKINETICS OF 5-Fu AFTER LEFT GASTRIC ARTERY INTRA-ARTERIAL INFUSION IN TREATMENT OF GASTRIC CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(1): 26-28. doi: Copy