ADVANCES IN TELOMERASE ACTIVITY OF GASTRIC CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WANG Yaxu

Department of General Surgery, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042;

Corresponding author：

Keywords：

Telomere Telomerase Gastric cancer

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Abstract Full text Figures/Tables Video References Cited by

Objective To introduce telomeres, telomerase and their expression in gastric carcinoma.
Methods The related literatures were collected and reviewed.
Rsults In summary, telomerase activity could be detected in 85%-90% of gastric cancer. Moreover, the patient with telomerase-positive tumors showed poorer prognosis than those with telomerase-negative tumours, indicating that telomerase-positive gastric cancer might have more malignant potential.
Conclusion Knowledge of telomerase activity in gastric cancer may be useful in cancer diagnosis, as well as a prognostic indicator of clinical outcome. Future development of drugs aimed at telomerase inhibition may potentially provide a therapy with relatively less side effects.

Citation： WANG Yaxu,WANG Daike.. ADVANCES IN TELOMERASE ACTIVITY OF GASTRIC CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(1): 56-58. doi: Copy

1.	Kim NW, Platyszek MA, Prowse KR, et al.Specific association of human teloymerase activity with immortal cells and cancer [J].Science, 1994; 266(5193)∶2011.
2.	Yu GL, Bradley JD, Attardi LD, et al.In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs [J]. Nature, 1990; 344(6262)∶126.
3.	Maruyama Y, Hanei H, Fujita M, et al.Telomere length and telomerase activity in carcinogenesis of the stomach [J]. Nippon Rinsho, 1998; 56(5)∶1186.
4.	Hiyama E, Hiyama K, Yokoyama T, et al.Correlating telomerase activity levels with human neuroblastoma outcomes [J]. Nat Med, 1995; 1(3)∶249.
5.	Hiyama K, Hiyama E, Ishioka S, et al.Telomerase activity in smallcell and nonsmallcell lung cancers [J]. N Natl Cancer Inst, 1995; 87(12)∶895.
6.	Chadeneau C, Hay K, Hirte HVV, et al.Telomerase activity associated with acquisition of malignancy in human colorectal cancer[J]. Cancer Res, 1995; 55(12)∶2533.
7.	Tahara H, Nakanishi T, Kitamoto M, et al.Telomerase activity in human liver tissues:comparison between chronic liver disease and hepotocellular carcinomas [J].Cancer Res, 1995; 55(13)∶2734.
8.	Hiyama E, Yokoyama T, Tatsumoto N, et al.Telomerase activity in gastric cancer [J]. Cancer Res, 1995; 55(15)∶3258.
9.	Hiyama E, Gollahon L, Kataoka T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1996; 88(2)∶116.
10.	Iwao T, Hiyama E, Yokoyama T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1997; 89(21)∶1121.
11.	Wright PA, Williams GT. Molecular biology and gastric carcinoma [J]. Gut, 1993; 34(2)∶145.
12.	杨仕明，房殿春，罗之辉等.胃癌及癌前组织中端粒酶活性的检测及临床意义 [J].中华医学杂志，1998； 78(3)∶207.
13.	杨仕明，房殿春，罗之辉等.胃癌组织中端粒酶活性的检测及临床意义 [J].第三军医大学学报，1997； 19(5)∶401.
14.	Ahn MJ, Nph YH, Lee YS, et al.Telomerase activity and its clinicopathological significance in gastric cancer [J]. Eur J Cancer, 1997; 33(8)∶1309.
15.	Tahara E, Semba S, Tahara H. Molecular biological observationa in gastric cancer [J]. Semin Oncol, 1996; 23(3)∶307.
16.	Kuniyasu H, Domen T, Hamamoto T, et al.Expression of human telomerase RNA is an early event of stomach carcinogenesis [J]. Jpn J Cancer Res, 1997; 88(2)∶103.
17.	Okusa Y, Shinomiya N, Ichikura T, et al.Correlation between telomerase activity and DNA ploicly in gastric cancer [J]. Oncology, 1998; 55(3)∶258.
18.	Ogawa K, Wakasugi S, Katsube T, et al.Relationship between telomerase activity and clinicopathological findings in gastric cancer [J]. 1998; 56(5)∶1194.
19.	卫建平，王晨，王晶晶等.端粒酶HTR在癌及癌前病变中表达的意义探讨 [J].山西医药杂志，1998； 27(3)∶196.
20.	Ichikura T, Okusa Y, Mochizuki H. Telomerase activity during the cell cycle in gastric cancer cell lines [J]. Nippon Rinsho, 1998; 56(5)∶1199.

1. Kim NW, Platyszek MA, Prowse KR, et al.Specific association of human teloymerase activity with immortal cells and cancer [J].Science, 1994; 266(5193)∶2011.
2. Yu GL, Bradley JD, Attardi LD, et al.In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs [J]. Nature, 1990; 344(6262)∶126.
3. Maruyama Y, Hanei H, Fujita M, et al.Telomere length and telomerase activity in carcinogenesis of the stomach [J]. Nippon Rinsho, 1998; 56(5)∶1186.
4. Hiyama E, Hiyama K, Yokoyama T, et al.Correlating telomerase activity levels with human neuroblastoma outcomes [J]. Nat Med, 1995; 1(3)∶249.
5. Hiyama K, Hiyama E, Ishioka S, et al.Telomerase activity in smallcell and nonsmallcell lung cancers [J]. N Natl Cancer Inst, 1995; 87(12)∶895.
6. Chadeneau C, Hay K, Hirte HVV, et al.Telomerase activity associated with acquisition of malignancy in human colorectal cancer[J]. Cancer Res, 1995; 55(12)∶2533.
7. Tahara H, Nakanishi T, Kitamoto M, et al.Telomerase activity in human liver tissues:comparison between chronic liver disease and hepotocellular carcinomas [J].Cancer Res, 1995; 55(13)∶2734.
8. Hiyama E, Yokoyama T, Tatsumoto N, et al.Telomerase activity in gastric cancer [J]. Cancer Res, 1995; 55(15)∶3258.
9. Hiyama E, Gollahon L, Kataoka T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1996; 88(2)∶116.
10. Iwao T, Hiyama E, Yokoyama T, et al.Telomerase activity for the preoperative diagnosis of pancreatic cancer [J]. J Natl Cancer Inst, 1997; 89(21)∶1121.
11. Wright PA, Williams GT. Molecular biology and gastric carcinoma [J]. Gut, 1993; 34(2)∶145.
12. 杨仕明，房殿春，罗之辉等.胃癌及癌前组织中端粒酶活性的检测及临床意义 [J].中华医学杂志，1998； 78(3)∶207.
13. 杨仕明，房殿春，罗之辉等.胃癌组织中端粒酶活性的检测及临床意义 [J].第三军医大学学报，1997； 19(5)∶401.
14. Ahn MJ, Nph YH, Lee YS, et al.Telomerase activity and its clinicopathological significance in gastric cancer [J]. Eur J Cancer, 1997; 33(8)∶1309.
15. Tahara E, Semba S, Tahara H. Molecular biological observationa in gastric cancer [J]. Semin Oncol, 1996; 23(3)∶307.
16. Kuniyasu H, Domen T, Hamamoto T, et al.Expression of human telomerase RNA is an early event of stomach carcinogenesis [J]. Jpn J Cancer Res, 1997; 88(2)∶103.
17. Okusa Y, Shinomiya N, Ichikura T, et al.Correlation between telomerase activity and DNA ploicly in gastric cancer [J]. Oncology, 1998; 55(3)∶258.
18. Ogawa K, Wakasugi S, Katsube T, et al.Relationship between telomerase activity and clinicopathological findings in gastric cancer [J]. 1998; 56(5)∶1194.
19. 卫建平，王晨，王晶晶等.端粒酶HTR在癌及癌前病变中表达的意义探讨 [J].山西医药杂志，1998； 27(3)∶196.
20. Ichikura T, Okusa Y, Mochizuki H. Telomerase activity during the cell cycle in gastric cancer cell lines [J]. Nippon Rinsho, 1998; 56(5)∶1199.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

ADVANCES IN TELOMERASE ACTIVITY OF GASTRIC CANCER

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