• Department of General Surgery, The First Affiliated Hospital, China University of Medical Sciences, Shenyang 110001;
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Objective  To investigate the relationship between microvessel density(MVD) and lymph node metastasis and prognosis in gallbladder carcinoma.
Methods The MVD in 42 gallbladder carcinoma by immunohistochemical SP method using a polyclonal antibody to FⅧ and the relationship between MVD and histologic types, depth of invasion, lymph node metastasis, distant metastasis and prognosis was studied.
Results  The value of MVD was correlated with the depth of invasion (P<0.05), lymph node metastasis (P<0.01) and distant metastasis (P<0.05). It was not significantly related to the pathologic pattern and tumor differentiation. The significantly negtive correlation was found between MVD and 5-year survival in patients with gallbladder carcinoma.
Conclusion  MVD is bly related to the metastasis of gallbladder carcinoma. It may serve as a prognotic factor.

Citation: BAI Tao,GUO Renxuan,WANG Hao.. RELATIONSHIP OF ANGIOGENESIS WITH PROGRESSION AND PROGNOSIS OF GALLBLADDER CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(2): 101-103. doi: Copy