Objective To investigate the growth of tumors and the natural life length of the rats after the adriamycinethylcellulose microspheres(ADM-EC mc) were injected in the rats bearing transplantable liver cancer through their hepatic arteries.
Methods ADM-EC mc were infused into the proper hepatic arteries of the Wistar rats (W256). All of the rats were divided randomly into five groups, group 1: control, group 2: normal saline, group 3: conventional ADM, group 4: placebo ethylcellulose microspheres, and group 5: ADM-EC mc.
Results As compared with other four groups, the ADM-EC mc (group 5) showed the best inhibition of the growth of tumors and the longest mean life length of the rats.
Conclusion Hepatic arterial infusion of ADM-EC mc can inhibit the growth of the tumor, aggravate the necrosis, and improve the effects of the chemotherapy of liver cancer.
Citation：
PENG Fangxing,YAN Lnan,LIN Qiyuan,et al.. HEPATIC ARTERIAL CHEMOEMBOLIZATION OF ADRIAMYCIN-ETHYLCELLULOSE MICROSPHERES IN THE TREATMENT OF LIVER CANCER IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 138-140. doi:
Copy
| 1. |
Kato T, Young K. Arterial chemoembolization with mitomycin microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrap elvic organs 〔J〕. Cancer, 1981； 48(3)∶674.
|
| 2. |
Najib N, Suleiman MS. The Kinetics of drug release from ethy cellulose solid dipersions 〔J〕. Drug Dev Ind Pharm, 1985； 11(12)∶2169.
|
| 3. |
盛浩，魏树礼.阿霉素毫微球制剂的研究进展 〔J〕.国外医学合成药、生化药、制剂分册，1996； 17(1)∶34.
|
| 4. |
王义，吴孟超，张晓华等.肝动脉注射顺铂乙基纤维素微囊后血液及重要器官全面的分布研究 〔J〕.中华外科杂志，1990； 28(11)∶686.
|
| 5. |
杨继金，朱永法，左龙京等.大白鼠转移性肝癌模型的制作 〔J〕.中华放射学杂志，1993； 27(2)∶122.
|
| 6. |
Kan ZX, Krassnodar I, Anders L, et al. In vivo microscopy of hepatic tumors in animal model: a dynamic investigation of blood supply to hepatic metastasis 〔J〕. Radiology, 1993； 187(3)∶621.
|
| 7. |
张志荣，王丹，廖方义等.肝动脉栓塞米托蒽醌乙基纤维素微球的研究 〔J〕.药学学报，1996； 31(8)∶626.
|
- 1. Kato T, Young K. Arterial chemoembolization with mitomycin microcapsules in the treatment of primary or secondary carcinoma of the kidney, liver, bone and intrap elvic organs 〔J〕. Cancer, 1981； 48(3)∶674.
- 2. Najib N, Suleiman MS. The Kinetics of drug release from ethy cellulose solid dipersions 〔J〕. Drug Dev Ind Pharm, 1985； 11(12)∶2169.
- 3. 盛浩，魏树礼.阿霉素毫微球制剂的研究进展 〔J〕.国外医学合成药、生化药、制剂分册，1996； 17(1)∶34.
- 4. 王义，吴孟超，张晓华等.肝动脉注射顺铂乙基纤维素微囊后血液及重要器官全面的分布研究 〔J〕.中华外科杂志，1990； 28(11)∶686.
- 5. 杨继金，朱永法，左龙京等.大白鼠转移性肝癌模型的制作 〔J〕.中华放射学杂志，1993； 27(2)∶122.
- 6. Kan ZX, Krassnodar I, Anders L, et al. In vivo microscopy of hepatic tumors in animal model: a dynamic investigation of blood supply to hepatic metastasis 〔J〕. Radiology, 1993； 187(3)∶621.
- 7. 张志荣，王丹，廖方义等.肝动脉栓塞米托蒽醌乙基纤维素微球的研究 〔J〕.药学学报，1996； 31(8)∶626.
