EXPRESSION AND SIGNIFICANCE OF CYCLIN D1， CYCLINE AND P27 IN GASTRIC CARCINOMAS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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The Second People’s Hospital of Wuxi city of Jiangsu Province, Wuxi 214002;

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Gastric carcinoma Cyclin D1 Cyclin Ep27 proteinImmunohistochemistry

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Objective To study the expression and its significance of cyclin D1,cyclin E and p27 protein in gastric carcinoma.
Methods The expression of cyclin D1,cyclin E and p27 protein in 60 cases of gastric carcinoma were detected by immunostaining method.
Results The positive rates of cyclin D1,cyclin E and p27 protein expression in gastric carcinoma were 41.7%（25/60）,38.3%（23/60）and 36.7%（22/60）,respectively.The expression of cyclin D1 was significantly correlated with Lauren type of tumor,the expression of cyclin E was significantly correlated with tumor differentiation,infiltration and stage,while the expression of p27 protein was significantly correlated with tumor infiltration,lymph nodes metastasis and stage. Further more, the expression of cyclin E was inversely correlated with the expression of p27.
Conclusion Detection of cyclin D1,cyclin E and p27 expression in gastric carcinoma may be helpful in determining tumor progression.

Citation： XIA Jiazeng,YANG Jichang,ZHANG Rongrong,et al.. EXPRESSION AND SIGNIFICANCE OF CYCLIN D1， CYCLINE AND P27 IN GASTRIC CARCINOMAS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 148-150. doi: Copy

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1. Lazzereschi D,Sanbuco L,Scalzo CC,et al.Cyclin D1 and cyclin E expression in malignant thyroid cells and in human thyroid carcinomas 〔J〕. Int J Cancer,1998； 76(6)∶806.
2. Muller W,Noguchi T,Wirtz HC,et al.Expression of cellcycle regulatory proteins cyclin D1,cyclin E,and their inhibitor p21 waf 1/cip 1 in gastric cancer 〔J〕. J Pathol,1999； 189(1)∶186.
3. Kim SJ,Lee JB,Kim CS,et al.Cyclin D1 and p21 expression in gastric adenocarcinoma 〔C〕.3rd. International Gastric Cancer Congress, 1999∶359~360.
4. Yasui W,Akama Y,Kuniyasu H,et al.Expression of cyclin E in human gastric adenomas and adenocarcinomas: correlation with proliferative activity and p53 status 〔J〕. J Exp Ther Oncol,1996； 1(1)∶88.
5. Yasui W,Kudo Y,Semba S,et al.Reduced expression of cyclindependent kinase inhibitor p27 kip1 is associated with advanced stage and invasiveness of gastric carcinomas 〔J〕.Jpn J Cancer Res,1997； 88(7)∶625.
6. Fredersdorf S,Burns J,Milne AM,et al.High level expression of p27 kip1 and cyclin D1 in some human breast cancer cells:inverse correlation between the expression of p27 kip1 and degree of malignancy in human breast and colorectal cancers 〔J〕.Proc Natl Acad Sci USA,1997； 94(12)∶6380.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION AND SIGNIFICANCE OF CYCLIN D1， CYCLINE AND P27 IN GASTRIC CARCINOMAS

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