XU Zhifei 1 , TIAN Qi 2 , HE Sheng. 2
  • Department of Surgery, Hospital of Meishan Rolling Stock Works, Meishan 612163;
Gallstone Glucose metabolism Lipid metabolism
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Objective  To study the effects of glucose and lipid metabolism on gallstone formation.
Methods  Twenty five patients with gallstones and 25 normal volunteer controls were studied from January to April in 1998. The patients were well matched the control with sex and age (1∶1). In the study, Body Mass Index (BMI) and Waist-to-Hip circumference ratio (W/H) were measured. Blood glucose, glucosylated hemoglobin (HbA1C), insulin, C peptide and all parameters of lipids were detected at fasting state. The glucose,insulin, C peptide were detected again at 2-hour after taking 75g glucose orally.
Results  The result showed there was no difference on BMI and W/H between the patients and controls. HbA1C、mean fasting and 2hour glucose concentration were not in significantly different between the two groups (P gt;0.05, P gt;0.2, P gt;0.1 respectively). There were 10 patients with abnormal glucose metabolism (7 with NIDDM, 3 with IGT), but only 4 controls were abnoumal (one with NIDDM, three with IGT). The difference was significant (P lt;0.05). Furthermore, the mean fasting and 2hour insulin concentration of gallstone group was higher than that of the control (P lt;0.02, P lt;0.05). And the gallstone group had a higher fasting C peptide concentration than control (P lt;0.05). There was no statistical difference on the parameters of plasma lipid between the tow groups.
Conclusion  The study suggests that diabetes mellious and hyperinsulinemia acted as an important role on gallstone formation.

Citation： XU Zhifei,TIAN Qi,HE Sheng.. RELATIONSHIP BETWEEN GALLBLADDER STONE AND LIPOROGLUCOSE METABOLISM. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 159-161下转163. doi: Copy