VASCULAR ENDOTHELIAL GROWTH FACTOR AND TUMOR ANGIOGENESIS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

YANG Yijun

Lab of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Medical University, Xi’an 710061;

Corresponding author：

Keywords：

Vascular endothelial growth factor Neoplasm Angiogenesis Therapy

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Objective To evaluate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis, and its usage in tumor therapy.
Methods The recent literatures about VEGF and angiogenesis were reviewed and analyzed. The advances of VEGF study were summarized. The effects of anti-angiogenesis in tumor biological therapy were introduced.
Results Angiogenesis had been identified as an important factor for promoting tumor growth. VEGF was a basic and pivotal factor in tumor angiogenesis. The anti-angiogenesis treatments aimed at VEGF, including the applications of VEGF inhibitor and gene therapy of adenovirus medium, had got great progress.
Conclusion VEGF is a leading factor of tumor angiogenesis, the anti-angiogenesis therapy aimed at VEGF has probably provided a new chance to malignant tumor treatment.

Citation： YANG Yijun,SHI Jingsen.. VASCULAR ENDOTHELIAL GROWTH FACTOR AND TUMOR ANGIOGENESIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(3): 205-207. doi: Copy

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2.	Connolly DT, Heuvelman DM, Nelson R, et al.Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis 〔J〕. J Clin Invest, 1989； 84(5)∶1470.
3.	De Vries C, Escobedo JA, Ueno H, et al.The fmslike tyrosine kinase, a receptor for vascular endothelial growth factor 〔J〕. Science, 1992； 255(5047)∶989.
4.	Terman BI, DougherVermazen NM, Carrion ME, et al.Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor 〔J〕. Biochem Biophys Res Commun, 1992； 187(3)∶1579.
5.	Brock TA, Dvorak HF, Senger DR. Tumorsecreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells 〔J〕. Am J Pathol,1991； 138(1)∶213.
6.	Namiki A, Brogi E, Kearney M, et al.Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells 〔J〕. J Biol Chem, 1995； 270(52)∶31189.
7.	Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wildtype p53 and vSrc exert opposing influences on human vascular endothelial growth factor gene expression 〔J〕. Cancer Res,1995； 55(24)∶6161.
8.	McNamara DA, Harmey JH, Walsh TN, et al.Significance of angiogenesis in cancer therapy 〔J〕. Br J Surg,1998； 85(8)∶1044.
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10.	Saito H, Tsujitani S, Kondo A, et al.Expression of vascular endothelial growth factor correlates with hemotogenous recurrence in gastric carcinoma 〔J〕. Surgery, 1999； 125(2)∶195.
11.	Arbiser JL, Moses MA, Fernandez CA, et al.Oncogenic Hras stimulates tumor angiogenesis by two distinct pathways 〔J〕. Proc Nat Acad Sci USA,1997； 94(3)∶861.
12.	Maniwa Y, Okada M, Ishii N, et al.Vascular endothelial growth factor increased by pulmonary suegery accelerates the growth of micrometastases in metastatic lung cancer 〔J〕. Chest, 1998； 114(6)∶1668.
13.	O’Reilly M, Holmgren L, Shing Y, et al.Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma 〔J〕. Cell, 1994； 79(2)∶315.
14.	Joe YA, Hong YK, Chung DS, et al.Inhibition of human malignant glioma growth in vivo by human recombinant plasminogen kringles 1-3 〔J〕. Int J Cancer, 1999； 82(5)∶694.
15.	Kirsch M, Strasser J, Allende R, et al.Angiostatin suppresses malignant glioma growth in vivo 〔J〕. Cancer Res, 1998； 58(20)∶4654.
16.	Asano M, Yukita A, Suzuki H. Wild spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor 〔J〕. Jpn J Cancer Res,1999； 90(1)∶93.
17.	Witte L, Hicklin DJ, Zhu Z, et al.Monoclonal antibodies targeting the VEGF receptor2 (F1k1/KDR) as an antiangiogenic therapeutic strategy 〔J〕. Cancer Metastasis Rev, 1998； 17(2)∶155.
18.	Arora N, Masood R, Zheng T, et al.Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells 〔J〕. Cancer Res,1999； 59(1)∶183.
19.	Riccioni T, Cirielli C, Wang X, et al. Adenovirusmediated wildtype p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo 〔J〕. Gene Ther, 1998； 5(6)∶747.
20.	Harada H, Nakagawa K, Iwata S, et al.Restoration of wildtype p16 downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas 〔J〕. Cancer Res,1999； 59(15)∶3783.
21.	Saleh M, Stacker SA, Wills AF. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor 〔J〕. Cancer Res,1996； 56(2)∶393.
22.	Gorski DH, Beckett MA, Jaskowiak NT, et al.Blockage of vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation 〔J〕. Cancer Res,1999； 59(14)∶3374.
23.	Shishido T, Yasoshima T, Denno R, et al.Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP470 in combination with cisplatin 〔J〕. Jpn J Cancer Res,1998； 89(9)∶963.

1. Senger DR, Galli SJ, Dvorak AM, et al.Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid 〔J〕. Science, 1983； 219(4587)∶983.
2. Connolly DT, Heuvelman DM, Nelson R, et al.Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis 〔J〕. J Clin Invest, 1989； 84(5)∶1470.
3. De Vries C, Escobedo JA, Ueno H, et al.The fmslike tyrosine kinase, a receptor for vascular endothelial growth factor 〔J〕. Science, 1992； 255(5047)∶989.
4. Terman BI, DougherVermazen NM, Carrion ME, et al.Identification of the KDR tyrosine kinase as a receptor for vascular endothelial growth factor 〔J〕. Biochem Biophys Res Commun, 1992； 187(3)∶1579.
5. Brock TA, Dvorak HF, Senger DR. Tumorsecreted vascular permeability factor increases cytosolic Ca2+ and von Willebrand factor release in human endothelial cells 〔J〕. Am J Pathol,1991； 138(1)∶213.
6. Namiki A, Brogi E, Kearney M, et al.Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells 〔J〕. J Biol Chem, 1995； 270(52)∶31189.
7. Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wildtype p53 and vSrc exert opposing influences on human vascular endothelial growth factor gene expression 〔J〕. Cancer Res,1995； 55(24)∶6161.
8. McNamara DA, Harmey JH, Walsh TN, et al.Significance of angiogenesis in cancer therapy 〔J〕. Br J Surg,1998； 85(8)∶1044.
9. Samoto K, Ikezaki K, Ono M, et al.Expression of vascular endothelial growth factor and its possible relation with neovascularization in human brain tumors 〔J〕. Cancer Res,1995； 55(5)∶1189.
10. Saito H, Tsujitani S, Kondo A, et al.Expression of vascular endothelial growth factor correlates with hemotogenous recurrence in gastric carcinoma 〔J〕. Surgery, 1999； 125(2)∶195.
11. Arbiser JL, Moses MA, Fernandez CA, et al.Oncogenic Hras stimulates tumor angiogenesis by two distinct pathways 〔J〕. Proc Nat Acad Sci USA,1997； 94(3)∶861.
12. Maniwa Y, Okada M, Ishii N, et al.Vascular endothelial growth factor increased by pulmonary suegery accelerates the growth of micrometastases in metastatic lung cancer 〔J〕. Chest, 1998； 114(6)∶1668.
13. O’Reilly M, Holmgren L, Shing Y, et al.Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma 〔J〕. Cell, 1994； 79(2)∶315.
14. Joe YA, Hong YK, Chung DS, et al.Inhibition of human malignant glioma growth in vivo by human recombinant plasminogen kringles 1-3 〔J〕. Int J Cancer, 1999； 82(5)∶694.
15. Kirsch M, Strasser J, Allende R, et al.Angiostatin suppresses malignant glioma growth in vivo 〔J〕. Cancer Res, 1998； 58(20)∶4654.
16. Asano M, Yukita A, Suzuki H. Wild spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor 〔J〕. Jpn J Cancer Res,1999； 90(1)∶93.
17. Witte L, Hicklin DJ, Zhu Z, et al.Monoclonal antibodies targeting the VEGF receptor2 (F1k1/KDR) as an antiangiogenic therapeutic strategy 〔J〕. Cancer Metastasis Rev, 1998； 17(2)∶155.
18. Arora N, Masood R, Zheng T, et al.Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells 〔J〕. Cancer Res,1999； 59(1)∶183.
19. Riccioni T, Cirielli C, Wang X, et al. Adenovirusmediated wildtype p53 overexpression inhibits endothelial cell differentiation in vitro and angiogenesis in vivo 〔J〕. Gene Ther, 1998； 5(6)∶747.
20. Harada H, Nakagawa K, Iwata S, et al.Restoration of wildtype p16 downregulates vascular endothelial growth factor expression and inhibits angiogenesis in human gliomas 〔J〕. Cancer Res,1999； 59(15)∶3783.
21. Saleh M, Stacker SA, Wills AF. Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor 〔J〕. Cancer Res,1996； 56(2)∶393.
22. Gorski DH, Beckett MA, Jaskowiak NT, et al.Blockage of vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation 〔J〕. Cancer Res,1999； 59(14)∶3374.
23. Shishido T, Yasoshima T, Denno R, et al.Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP470 in combination with cisplatin 〔J〕. Jpn J Cancer Res,1998； 89(9)∶963.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

VASCULAR ENDOTHELIAL GROWTH FACTOR AND TUMOR ANGIOGENESIS

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