IMMUNE RESPONSE IN PIG TO MONKEY VESSEL XENOTRANSPLANTATION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

WEN un , CHEN Gengzhen , SHEN Wenl.

Center of Transplantation, Second Affiliated Hospital, Shantou University of Medical College, Shantou 515041;

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Keywords：

Xenograft Hyperacute rejection Pig Monkey

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Objective To investigate the mechanism of hyperacute rejection (HAR) in pig to rhesus monkey vein xenograft. Methods Porcine femoral vein was transplanted into rhesus monkey. Deposits of IgM, IgG, C3 and C4 on the grafts were observed by immunoflurescence.
Results Great deal of IgM, C3 and C4 were seen along the endothelium of donor vein, but IgG was not seen. ConclusionIn pig to monkey xenograft model, HAR is intiated by the binding of xenoreactive IgM to donor xenoantigens and followed by the activation of complement via the classical pathway.

Citation： WEN un,CHEN Gengzhen,SHEN Wenl.. IMMUNE RESPONSE IN PIG TO MONKEY VESSEL XENOTRANSPLANTATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(4): 218-219. doi: Copy

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1. Cooper DKC, Ye Y, Kosanke S, et al. The pig as potential organ for man 〔M〕. In: Cooper DKC, Ye Y, Kosanke S, et al. Xenotransplantation. Heidelberg: Springer, 1991∶457-459.
2. Mckenzin IFC, Xing PX, Vaughan HA, et al. Distribution of the major xenoantigen (gal α 1,3gal) for pig to human xenografts 〔Ｊ〕. Transplant Immunology, 1994; 2∶81.
3. Lawson JH, Platt JL. Molecular barriers to xenotransplantation〔Ｊ〕. Transplantation, 1996; 62(2)∶303.
4. Miyagawa S, Hirose H, Shirakura R, et al. The mechanism of discordant xenograft rejection 〔Ｊ〕. Transplantation, 1988; 46(3)∶825.
5. Dalmasso AP, Vercellotti GM, Fishel RJ, et al. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients 〔Ｊ〕. Am Pathology, 1992; 140(6)∶1157.
6. Zhao Z, Termignon JL, Cardoso J, et al. Hyperacute xenograft rejection in the swinetohuman donorrecipient combination 〔Ｊ〕. Transplantation, 1994; 57(2)∶245.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

IMMUNE RESPONSE IN PIG TO MONKEY VESSEL XENOTRANSPLANTATION

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