• Department of Hepatobiliary Surgery, PLA 306th Hospital, Beijing 100101;
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【Abstract】Objective  To study the protective effects of anisodamine on liver ischemia-reperfusion injury in rats. Methods  One hundred and sixty male Wistar rats were randomly divided into the normal control (n=10), ischemiareperfusion (n=50), normal saline (n=50) and anisodamine (n=50, 2.0 mg/kg) groups. The animals were killed 1, 3, 6, 12, 24 hours after ischemia induced for 60 minutes and followed by reperfusion. Plasma endothelin-1 (ET-1), hyaluronic acid (HA), glutamic-pyruvic transaminase enzyme (ALT) were measured, and the hepatic histopathologic alterations were also observed. Results  The plasma ET-1, HA and ALT concentrations were markedly increased after liver ischemiareperfusion.The hepatic congestion was significantly obvious. An intravenous injection of anisodamine before ischemiareperfusion could decrease the plasma HA and ALT concentrations and relieve the hepatic congestion. Conclusion  Anisodamine can improve hepatic microcirculatory disturbances after reperfusion and have hepatoprotictive effects on rat liver ischemia-reperfusion injury.

Citation: DONG Manku,CUI Yan,CHEN Changwei,et al.. EXPERIMENTAL STUDY ON PROTECTIVE EFFECTS OF ANISODAMINE ON ISCHEMIA-REPERFUSION INJURY IN RAT LIVER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 295-297. doi: Copy