STUDY ON THE EXPRESSION OF p16 AND Rb IN THYROID CARCINOMA_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of General Surgery, Weihai Municipal Hospital，Weihai 264200;

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Keywords：

甲状腺癌; p16基因; Rb基因; 免疫组织化学

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【Abstract】Objective To demonstrate the role of p16 protein and Rb protein in the formation and progression and their relationship in thyroid carcinoma. Methods p16 and Rb from 46 patients with thyroid cancer were detected by SP immunohistochemistry. Results In thyroid carcinoma,the p16 positive rate was decreased with the decline of differentiation. There was an inverse correlation between the rates of p16 positive expression and involvement of lymph node,clinical stage and prognosis index.The Rb protein was not present in any cases as a nucleus staining.
Conclusion The p16 gene is likely to play an important role in the genesis and malignant progression of thyroid carcinoma,while the Rb gene is not .

Citation： WANG Ziliang,WANG Nong,GENG Jianli,et al.. STUDY ON THE EXPRESSION OF p16 AND Rb IN THYROID CARCINOMA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 319-321. doi: Copy

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1. Li Y, Nichols MA, Shay JW, et al. Transcriptional repression of the Dtype cyclindependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product PRb 〔Ｊ〕. Cancer Res, 1994; 54(23)∶6078.
2. Fromowitz FB, Viola MV, Chao S, et al. Res p21 expression in the progression of breast cancer 〔Ｊ〕. Human Pathol, 1987; 18(12)∶1268.
3. 王翠芳，腾猛，李迎旭等. p16蛋白在甲状腺癌的表达或缺失的意义〔Ｊ〕. 中国肿瘤临床， 1998； 25（3）∶221.
4. Serano M, Hannon GJ, Becach D. A new regulatory motif in cellcycle control causing specific inhibition of cyclin D/CDK4 〔Ｊ〕. Nature, 1993; 336(6456)∶704.
5. Kamb A, Gruis NA, WeaverFeldhaus J, et al. A cell cycle regulator potentially involved in genesis of many tumor types 〔Ｊ〕. Science, 1994; 264(5157)∶436.
6. Zou MU, Shi YE, Farid NR. Retinoblastoma gene defects are control to thyroid carcinogenesis 〔C〕. Endocrine Society Meeting, 1993∶91-4.
7. Holm R, Nesland JM. Retinoblastoma and p53 tumor suppressor gene protein expression in carcinomas of the thyroid gland 〔Ｊ〕. J Pathol, 1994; 172(3)∶267.
8. Xu HJ, Hu SX, Cagle PT, et al. Absence of retinoblastoma protein in primary nonsmallcell lung carcinomas 〔Ｊ〕. Cancer Res, 1991; 51(10)∶ 2735.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

STUDY ON THE EXPRESSION OF p16 AND Rb IN THYROID CARCINOMA

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