【Abstract】Objective The effects of tumor infiltrating lymphocytes (TIL) on cellular immunologic function of patients with breast cancer were studied. Methods Twenty five patients with breast cancer were treated by the TIL that were isolated from tissue of tumor. T cell subgroups and natural killer cell (NK cell) activity of peripheral blood, the levels of serum soluble interleukin-2 receptor (sIL-2R) were assayed before and after treatment. Results CD3, CD4, CD4/CD8 and NK cell activity were ascended obviously, and CD8, sIL-2R were descended obviously after the treatment of TIL. Conclusion TIL can enhance the cellular immunologic function of patients with breast cancer.
Citation：
LI Cheng,LU Junmin,GUAN Xin,et al.. EFFECTS OF TUMOR INFILTRATING LYMPHOCYTES ON CELLULAR IMMUNOLOGIC FUNCTION OF PATIENTS WITH BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 329-330. doi:
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顾琴龙，林言箴，尹浩然等. TIL细胞治疗对恶性肿瘤患者免疫功能的影响 〔Ｊ〕. 中国肿瘤临床， 1996； 23（3）∶184.
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- 1. Rosenberg SA, Spiess P, Diane S, et al. A new approach to theadoptive immunotherapy of cancer with tumorinfiltrating lymphocytes 〔Ｊ〕. Science, 1986; 233(4770)∶1318.
- 2. Whiteside TL, Miescher S, Mac Donald HR. Separation lymphocytes from tumor cells in human solid tumors. A comparison between velocity sedimentation and discontinuous density gradients 〔Ｊ〕. J Immunol Methods, 1986; 90(2)∶221.
- 3. 赵长春，王庭桂，杨春生主编. 临床免疫检验学 〔M〕. 天津： 天津科学技术出版社，1990∶ 351～364.
- 4. 刘剑勇，李挺，杨南武等. 肝癌疫苗激活的肿瘤浸润性淋巴细胞对血清sIL2R水平的影响及意义 〔Ｊ〕. 广西医学， 1999； 21（5）∶835.
- 5. 陈建思，陈汉华，刘剑仑等. 乳腺癌患者手术前后血清可溶性白细胞介素2受体水平的变化 〔Ｊ〕. 中国普外基础与临床杂志， 1999； 6（5）∶284.
- 6. 房家智，宋连生，叶红军等. 胃癌术后患者肿瘤浸润性淋巴细胞治疗的临床观察 〔Ｊ〕. 中国肿瘤临床， 1997； 24（11）∶869.
- 7. 顾琴龙，林言箴，尹浩然等. TIL细胞治疗对恶性肿瘤患者免疫功能的影响 〔Ｊ〕. 中国肿瘤临床， 1996； 23（3）∶184.
