THE IMPLICATION OF P75 NGFR EXPRESSION IN CONGENITAL CHOLEDOCHAL CYST_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Pediatric Surgery， First Affiliated Hospital， Shantou University Medical College,Shantou 515041;

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Congenital choledochal cyst Immunohistochemical Nerve growth factor receptor

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【Abstract】Objective To evaluate the distribution of nerve growth factor receptor( P75 NGFR) in congenital choledochal cyst(CCC) and its clinical implication. Methods Specimens from 18 children with CCC and normal choledochal specimens from 9 controls were immuno-stained with P75 NGFR antibody. Results Extensive P75 NGFR staining was found in the nerve fibres of normal comnon bile duct，bly staining of ganglion cells were observed on the normal specimens. There was very little immunoreactive fibre in the CCC. Conclusion The abnormal distribution of P75 NGFR in the aganglionic choledochal suggests that abnormal P75 NGFR is related to the occurrance of the CCC.

Citation： ZHENG Lian,HUANG Jiexiong,CHEN Jianzhong,et al.. THE IMPLICATION OF P75 NGFR EXPRESSION IN CONGENITAL CHOLEDOCHAL CYST. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 333-334. doi: Copy

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1. 童尔昌,季海萍主编.小儿腹部外科学〔M〕 . 北京: 人民卫生出版社,1991∶493~501.
2. Nathan J. Congenital cystic dilatation of the common bile duct〔J〕. Am J Surg, 1956； 91(1)∶56.
3. Hempstead BL, Zanca DM, Kaplan DR, et al. Highaffinity NGF binding requires coexpression of the trk protooncogene and the lowaffinity NGF receptor 〔Ｊ〕 . Nature,1991； 350(6)∶678.
4. 杨宏伟,王慧贞,李心元. 先天性胆总管囊肿末端狭窄神经分布的研究〔Ｊ〕 . 中华小儿外科杂志,1991； 12(3)∶144.
5. Chaudhuri PK,Chaudhuri B,Schuler J, et al. Carcinoma associated with congenital cystic dilatation of bile ducts 〔Ｊ〕 . Arch Surg，1982； 117(11)∶1349.
6. 王慧贞,曲日斌,王维林等.先天性胆总管扩张症远期疗效随访观察〔Ｊ〕 .中华小儿外科杂志,2000; 21(4)∶199.
7. Rabizadeh S, Oh J, Zhang LT, et al. Induction of apoptosis by the lowaffinity NGF receptor 〔Ｊ〕 . Science,1993； 261(3)∶345.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE IMPLICATION OF P75 NGFR EXPRESSION IN CONGENITAL CHOLEDOCHAL CYST

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