CREATION OF THE ANIMAL MODEL OF BONE METASTASIS OF BREAST CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

JIANG Guoqin ¹

Department of General Surgery, Second Affiliated Hospital, Suzhou University,Suzhou 215004;

Corresponding author：

Keywords：

Breast cancer Bone metastasis Animal model

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【Abstract】Objective To introduce three methods of creating the animal model of bone metastasis from breast cancer and the advances in the application of these models. Methods The related literatures were collected and reviewed.Results In summary, breast cancer cells injected through left ventricles was commonly used. Breast cancer cells injected into medullary cavity of shaft of femur was simple and effective, but it was very different from the real condition of bone metastasis of patients. The development of animal model created by surgical orthotopic implantation gives the researchs an ideal instrument similar with the condition of patients to research the mechanism of bone metastasis and the treatment. Conclusion Each animal model of bone metastasis from breast cancer has itself usefulness. Our destination is to create the real model of bone metastasis from breast cancer that is very similar with the patients.

Citation： JIANG Guoqin,ZHANG Zhide.. CREATION OF THE ANIMAL MODEL OF BONE METASTASIS OF BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(5): 355-357. doi: Copy

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3.	Mundy GR, Yoneda T. Mechanisms of bone metastasis.In：Orr FW, Singh GN， eds. Bone Metastasismechanisms and pathophysiology〔M〕. Austin, Texsas: R.G. Landes Co., 1996∶1-16.
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6.	Shevrin DH, Kukreja SC, Ghosh L, et al. Development of skeletal metastasis by human prostate cancer in athymic nude mice 〔Ｊ〕. Clin Exp Metastasis，1998； 6(5)∶401.
7.	Arguello F, Baqqs RB, Frantz CN, et al. A murine model of experimental metastasis to bone and bone marrow 〔Ｊ〕. Cancer Res，1988; 48(23)∶6876.
8.	Arguello F, Furlanetto RW， Baggs RB, et al. Incidence and distribution of experimental metastasis in mutant mice with defective organ microenvironments 〔Ｊ〕. Cancer Res, 1992; 52(8)∶2304.
9.	Sasaki A, Alcalde RE, Nishiyama A, et al. Angiogenesis inhibitor TNP470 inhibits human breast cancer osteolytic bone metastasis in nude mice trough the reduction of bone resorption 〔Ｊ〕. Cancer Res, 1998; 58(1)∶462.
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11.	Yoneda T, Michigami T, Yi B, et al. Actions of Bisphosphonate on bone metastasis in animal models of breast carcinoma 〔Ｊ〕. Cancer, 2000; 88(Suppl)∶2979.
12.	Guise TA. Molecular mechanisms of osteolytic bone metastasis 〔Ｊ〕. Cancer, 2000; 88(Suppl)∶2892.
13.	Kjonniksen I, Breistoi K, Fodstad O,et al. Site dependent differences in sensitivity of LOX human melanoma tumors in nude rats to dacarbazine and mitozolomide, but not to doxorubicin and cisplatin 〔Ｊ〕. Cancer Res, 1992; 52(5)∶1374.
14.	Arguello F, Baggs RB, Eskenazi AE, et al. Vascular anatomy and organspecific tumor growth as critical factors in the development of metastasis and their distribution among organs 〔Ｊ〕. Int J Cancer, 1991; 48(4)∶583.
15.	Nicolson GL. Cancer progression and growth： relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis 〔Ｊ〕. Exp Cell Res, 1993; 204(2)∶171.
16.	Kjonniksen I, Winderen M, Bruland O, et al. Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats 〔Ｊ〕. Cancer Res, 1994; 54(7)∶1715.
17.	Wang CY, Chang YW. A model for osseous metastasis of human breast cancer established by intrafemur injection of the MDAMB435 cells in nude mice 〔Ｊ〕. Anticancer Res, 1997; 17(4A)∶2471.
18.	Price JE, Polyzos A, Zhang RD, et al. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice 〔Ｊ〕. Cancer Res, 1990; 50(3)∶717.
19.	Lelekakis M, Moseley JM, Martin TJ, et al. A novel orthotopic model of breast cancer metastasis to bone 〔Ｊ〕. Clin Exp Metastasis,1999; 17(2)∶163.
20.	Hoffman RM. Orthotopic metastatic mouse models for anticancer drug and evaluation： a bridge to the clinic 〔Ｊ〕. Invest New Drugs, 1999; 17(4)∶343.
21.	Kurebayashi J, Nukatsuka M, Fujioka A, et al. Postsurgerical oral administration of uracil and tegafur inhibits progression of micrometastasis of human breast cancer cells in nude mice 〔Ｊ〕. Clin Cancer Res, 1997; 3(5)∶653.

1. Mundy GR. Mechanisms of bone metastasis 〔Ｊ〕. Cancer,1997; 80(8 Suppl)∶1546.
2. Paget S. The distribution of secondary growths in cancer of the breast 〔Ｊ〕. Lancet, 1889; 1（5）∶571.
3. Mundy GR, Yoneda T. Mechanisms of bone metastasis.In：Orr FW, Singh GN， eds. Bone Metastasismechanisms and pathophysiology〔M〕. Austin, Texsas: R.G. Landes Co., 1996∶1-16.
4. Crichton MB, Nichols JE, Zhao Y, et al. Expression of transcripts of interleukin6 and related cytokines by human breast tumors,breast cancer cells,and adipose stromal cells 〔Ｊ〕.Mol Cell Endocrinol，1996; 118(1-2)∶215.
5. Lacroix M, Siwek B, Marie PJ, et al. Production and regulation of interleukin 11 by breast cancer cells 〔Ｊ〕.Cancer Lett, 1998; 127(1-2)∶29.
6. Shevrin DH, Kukreja SC, Ghosh L, et al. Development of skeletal metastasis by human prostate cancer in athymic nude mice 〔Ｊ〕. Clin Exp Metastasis，1998； 6(5)∶401.
7. Arguello F, Baqqs RB, Frantz CN, et al. A murine model of experimental metastasis to bone and bone marrow 〔Ｊ〕. Cancer Res，1988; 48(23)∶6876.
8. Arguello F, Furlanetto RW， Baggs RB, et al. Incidence and distribution of experimental metastasis in mutant mice with defective organ microenvironments 〔Ｊ〕. Cancer Res, 1992; 52(8)∶2304.
9. Sasaki A, Alcalde RE, Nishiyama A, et al. Angiogenesis inhibitor TNP470 inhibits human breast cancer osteolytic bone metastasis in nude mice trough the reduction of bone resorption 〔Ｊ〕. Cancer Res, 1998; 58(1)∶462.
10. Yoneda T, Sasaki A, Dunstan C, et al. Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase2 〔Ｊ〕.J Clin Invest, 1997; 99(10)∶2509.
11. Yoneda T, Michigami T, Yi B, et al. Actions of Bisphosphonate on bone metastasis in animal models of breast carcinoma 〔Ｊ〕. Cancer, 2000; 88(Suppl)∶2979.
12. Guise TA. Molecular mechanisms of osteolytic bone metastasis 〔Ｊ〕. Cancer, 2000; 88(Suppl)∶2892.
13. Kjonniksen I, Breistoi K, Fodstad O,et al. Site dependent differences in sensitivity of LOX human melanoma tumors in nude rats to dacarbazine and mitozolomide, but not to doxorubicin and cisplatin 〔Ｊ〕. Cancer Res, 1992; 52(5)∶1374.
14. Arguello F, Baggs RB, Eskenazi AE, et al. Vascular anatomy and organspecific tumor growth as critical factors in the development of metastasis and their distribution among organs 〔Ｊ〕. Int J Cancer, 1991; 48(4)∶583.
15. Nicolson GL. Cancer progression and growth： relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis 〔Ｊ〕. Exp Cell Res, 1993; 204(2)∶171.
16. Kjonniksen I, Winderen M, Bruland O, et al. Validity and usefulness of human tumor models established by intratibial cell inoculation in nude rats 〔Ｊ〕. Cancer Res, 1994; 54(7)∶1715.
17. Wang CY, Chang YW. A model for osseous metastasis of human breast cancer established by intrafemur injection of the MDAMB435 cells in nude mice 〔Ｊ〕. Anticancer Res, 1997; 17(4A)∶2471.
18. Price JE, Polyzos A, Zhang RD, et al. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice 〔Ｊ〕. Cancer Res, 1990; 50(3)∶717.
19. Lelekakis M, Moseley JM, Martin TJ, et al. A novel orthotopic model of breast cancer metastasis to bone 〔Ｊ〕. Clin Exp Metastasis,1999; 17(2)∶163.
20. Hoffman RM. Orthotopic metastatic mouse models for anticancer drug and evaluation： a bridge to the clinic 〔Ｊ〕. Invest New Drugs, 1999; 17(4)∶343.
21. Kurebayashi J, Nukatsuka M, Fujioka A, et al. Postsurgerical oral administration of uracil and tegafur inhibits progression of micrometastasis of human breast cancer cells in nude mice 〔Ｊ〕. Clin Cancer Res, 1997; 3(5)∶653.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

CREATION OF THE ANIMAL MODEL OF BONE METASTASIS OF BREAST CANCER

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