THE INFLUENCES OF DONOR BLOOD INJECTION UPON PROLONGATION OF PANCREATIC ALLOGRAFT SURVIVAL IN RATS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

SUN Zhijun , YAO Zhenxiang.

Research Laboratory of Organ Transplantation, College of Clinical Medicine, Chongqing University of Medical Sciences, Chongqing 400016;

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Keywords：

Rat Donor-specific transfusion Pancreas transplant Graft survival

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【Abstract】Objective To investigate the effect of donor blood transfusion on inducing pancreatic allograft tolerance in outbred rat model. Methods Wistar male rats were used as blood and pancreas donor, and diabetic recipients. One ml of donor blood injected into abdomen of diabetic recipients on the day of transplantation and azathioprine given 2 days pretransplant and continued for three days. Results Pancreas allograft survival was significantly prolonged (28 to 112 days, media survival time 64.2 days). One ml of donor blood alone injected into the abdomen and azathioprine given alone 2 days pretransplant did not improve allograft survival (media survival time 9.8 vs 10.2 days). Conclusion Donor blood injected on the day of transplantation and a 3 days course of azathioprine started 2 days pretransplant have b synergism in inducing long term graft survival in this rat model.

Citation： SUN Zhijun,YAO Zhenxiang.. THE INFLUENCES OF DONOR BLOOD INJECTION UPON PROLONGATION OF PANCREATIC ALLOGRAFT SURVIVAL IN RATS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 364-366. doi: Copy

1.	Bushell A, Morris PJ, Wood KJ. Induction of operational tolerance by random blood transfusion combined with antiCD4 antibody therapy 〔Ｊ〕. Transplantation, 1994; 58(2)∶ 133.
2.	Vogt P, Hiller WFA, Steiniger B, et al. Differential response of kidney and pancreas rejection to cyclosporine immunosuppression 〔Ｊ〕. Transplantation, 1992; 53(6)∶ 1269.
3.	Klempnauer J, Vogt P, Hiller WFA. Donorspecific tolerance induced by nonmajor histocompatibility complex disparate kidney grafts for subsequent pancreas transplants 〔Ｊ〕. Transplant Pro, 1993; 25(1)∶373.
4.	Tchervenkdv JI, Cofer BR, Davies C, et al. Indefinite allograft survival induced by the combination of multiple donorspecific transfusions, cyclosporine, and an antiT cell monoclonal antibody in a protocol relevant to cadaveric organ transplantation 〔Ｊ〕. Transplantation, 1995; 59(6)∶821.
5.	Takiff H, Novak M, Iwaki Y, et al. Lowdose cyclosporine maintenance therapy after immunosupressive induction in a rat cardiac transplant model 〔Ｊ〕. Transplantation, 1988; 45(2)∶297.
6.	毕爱华.免疫应答(二)免疫耐受.见: 毕爱华主编.医学免疫学〔M〕. 第1版. 北京: 人民军医出版社, 1995∶123~129.
7.	Bayle F, Masson D, Zaoul P, et al. Beneficial effect of one HLA haplo or semiidentical transfusion versus three untyped blood units on alloimmunization and acute rejection episodes in first renal allograft recipients 〔Ｊ〕. Transplantation, 1995; 59(5)∶719.
8.	Flye MW, Burton K, Mohanakumar T, et al. Donorspecific transfusions have longterm beneficial effects for human renal allografts 〔Ｊ〕. Transplantation, 1995; 60(12)∶1395.
9.	Van Twuvver E, Mooijaart RJD, Ten Berge IJM, et al. Pretransplantation blood transfusion revisited 〔Ｊ〕. N Eng J Med, 1991; 325(17)∶1210.
10.	Brunson M, Tchervenkov JI, Alexander JW, et al. Enhancement of allograft survival by donorspecific transfusion one day prior to transplant 〔Ｊ〕. Transplantation, 1991; 52(4)∶ 543.
11.	Levy AE, Alexander JW. Administration of intragraft interleukin4 prolongs cardiac allograft survival in rats treated with donorspecific transfusion/cyclosporine 〔Ｊ〕. Transplantation, 1995; 60(5)∶405.

1. Bushell A, Morris PJ, Wood KJ. Induction of operational tolerance by random blood transfusion combined with antiCD4 antibody therapy 〔Ｊ〕. Transplantation, 1994; 58(2)∶ 133.
2. Vogt P, Hiller WFA, Steiniger B, et al. Differential response of kidney and pancreas rejection to cyclosporine immunosuppression 〔Ｊ〕. Transplantation, 1992; 53(6)∶ 1269.
3. Klempnauer J, Vogt P, Hiller WFA. Donorspecific tolerance induced by nonmajor histocompatibility complex disparate kidney grafts for subsequent pancreas transplants 〔Ｊ〕. Transplant Pro, 1993; 25(1)∶373.
4. Tchervenkdv JI, Cofer BR, Davies C, et al. Indefinite allograft survival induced by the combination of multiple donorspecific transfusions, cyclosporine, and an antiT cell monoclonal antibody in a protocol relevant to cadaveric organ transplantation 〔Ｊ〕. Transplantation, 1995; 59(6)∶821.
5. Takiff H, Novak M, Iwaki Y, et al. Lowdose cyclosporine maintenance therapy after immunosupressive induction in a rat cardiac transplant model 〔Ｊ〕. Transplantation, 1988; 45(2)∶297.
6. 毕爱华.免疫应答(二)免疫耐受.见: 毕爱华主编.医学免疫学〔M〕. 第1版. 北京: 人民军医出版社, 1995∶123~129.
7. Bayle F, Masson D, Zaoul P, et al. Beneficial effect of one HLA haplo or semiidentical transfusion versus three untyped blood units on alloimmunization and acute rejection episodes in first renal allograft recipients 〔Ｊ〕. Transplantation, 1995; 59(5)∶719.
8. Flye MW, Burton K, Mohanakumar T, et al. Donorspecific transfusions have longterm beneficial effects for human renal allografts 〔Ｊ〕. Transplantation, 1995; 60(12)∶1395.
9. Van Twuvver E, Mooijaart RJD, Ten Berge IJM, et al. Pretransplantation blood transfusion revisited 〔Ｊ〕. N Eng J Med, 1991; 325(17)∶1210.
10. Brunson M, Tchervenkov JI, Alexander JW, et al. Enhancement of allograft survival by donorspecific transfusion one day prior to transplant 〔Ｊ〕. Transplantation, 1991; 52(4)∶ 543.
11. Levy AE, Alexander JW. Administration of intragraft interleukin4 prolongs cardiac allograft survival in rats treated with donorspecific transfusion/cyclosporine 〔Ｊ〕. Transplantation, 1995; 60(5)∶405.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE INFLUENCES OF DONOR BLOOD INJECTION UPON PROLONGATION OF PANCREATIC ALLOGRAFT SURVIVAL IN RATS

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