• Department of General Surgery, The First Affiliated Hospital, Guangxi University of Medical Sciences, Nanning 530021;
Arsenic trioxide Hepatic carcinoma cell line MTT assay Anticancer drug
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【Abstract】Objective  To study the effects of arsenic trioxide (As2O3) on inhibiting the proliferation of hepatic carcinoma cell lines. Methods  To detect the inhibiting rate of As2O3 and other 6 kinds of anticancer drugs (such as, NOV, ADM, MMC, 5-Fu, DDP and CTX) on hepatic carcinoma cell lines BEL-7404 and SMMC-7721 by using MTT assay. Results  As compared with other 6 kinds of anticancer drugs, the inhibiting rate of As2O3 was the highest one (P＜0.01 or P＜0.05). The inhibiting rates of As2O3 in the groups with the concentration above 1.0 μg/ml were no different (P＞0.05). Conclusion  As2O3 could inhibit hepatic carcinoma cell lines BEL-7404 and SMMC-7721 effectively in vitro. Drug sensitivity tests of different concentration’s As2O3 should be done in order to select the minimal and effective concentration of arsenic trioxide and reduce the side effects of arsenic trioxide.

Citation： CHEN Junqiang,LI Shaosen,PENG Minghao,et al.. EXPERIMENTAL STUDY ON ARSENIC TRIOXIDE AND OTHER 6 KINDS OF ANTI-TUMOR DRUGS’EFFECTS ON HUMAN HEPATIC CANCER CELL LINES BEL-7404, SMMC-7721. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 2001, 8(6): 367-369. doi: Copy