In order to observe activity of tumor necrosis factor (TNF) in the serum, pancreatic histopathological damage, as well as their relationships in acute necrotizing pancreatitis (ANP), thirty five SD rats were randomly divided into 7 groups according to their sampling time with 5 in each group. ANP was induced by retrograde infusion of 5% sodium taurocholate through biliopancreatic duct in 6 experimental groups (Group B1～B6).Blood and pancreatic tissue samples were obtained at hour 0,0.5,2,4,6 or 8 respectively when the animals were sacrificed.Results showed that serum level of TNF activity rose significantly in Group B2,and reached the maximal value in Group B4.The pancreatic histopathological damage in ANP rats was getting worse along with time. Serum TNF activity had close relation to pancreatic histopathological score (r=0.63, Ｐ＜0.01),suggesting that serum TNF may play an important role in the process of deterioration of pancreatic tissue damage during ANP.
Citation：
Tian Bole,Zhang Zhaoda,Fu Lan,et al.. A STUDY OF SERUM TUMOR NECROSIS FACTOR ACTIVITY AND PANCREATIC TISSUE DAMAGE IN ACUTE NECROTIZING PANCREATITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(1): 13-14. doi:
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Exley AR, Leese T, Holliday MP, et al. Endotoxaemia and tumor necrosis factor as prognostic markers in severe acute pancreatitis.Gut, 1992; 33(8)∶1126.
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Grewal HP, Mohey el Din A, Gaber L, et al. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an antiTNFα polyclonal antibody. Am J Surg, 1994; 167(1)∶214.
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Eichacker PQ, Hoffman WD, Farese A, et al. TNF but not IL1 in dogs causes lethal injury and multiple organ dysfunction similar to human sepsis. J Appl Physiol, 1991; 71(5)∶1979.
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Mckay CJ, Gallayher G, Brooks B, et al. Increased monocyte cytokine production in association with systemic complication in acute pancreatitis. Br J Surg, 1996; 83(7)∶919.
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王建承， 赵小团， 袁祖荣等. 肿瘤坏死因子在急性胰腺炎及并发多器官衰竭中作用的研究. 中华医学杂志， 1995； 75(3)∶133.
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- 1. Exley AR, Leese T, Holliday MP, et al. Endotoxaemia and tumor necrosis factor as prognostic markers in severe acute pancreatitis.Gut, 1992; 33(8)∶1126.
- 2. Grewal HP, Mohey el Din A, Gaber L, et al. Amelioration of the physiologic and biochemical changes of acute pancreatitis using an antiTNFα polyclonal antibody. Am J Surg, 1994; 167(1)∶214.
- 3. Eichacker PQ, Hoffman WD, Farese A, et al. TNF but not IL1 in dogs causes lethal injury and multiple organ dysfunction similar to human sepsis. J Appl Physiol, 1991; 71(5)∶1979.
- 4. Mckay CJ, Gallayher G, Brooks B, et al. Increased monocyte cytokine production in association with systemic complication in acute pancreatitis. Br J Surg, 1996; 83(7)∶919.
- 5. 王建承， 赵小团， 袁祖荣等. 肿瘤坏死因子在急性胰腺炎及并发多器官衰竭中作用的研究. 中华医学杂志， 1995； 75(3)∶133.
