To evaluate the relations between the protein nm23 expression and infiltration and metastasis of gastric cancer. Sixty seven samples of gastric cancer resected were examined with LSAB-immunohistochemical method, and the protein nm23 expression in gastric cancer cells were studied. Results: Total positive rate of the protein nm23 expression in gastric cancer cells was 68.7%. There were significant differences among different histopathological types degrees of differentiation, extent of infiltrative and metastasis (Ｐ＜0.05). Conclusion: The positive rate of protein nm23 expression in gastric cancer cells is 68.7%, which is highly related to the pathological type degree of differentiation, extent of infiltration and metastasis of the tumor.
Citation：
Tan Jianmei,Fang Guoen,Wen Zhaozhang,et al.. THE SIGNIFICANCE OF PROTEIN nm23 EXPRESSION IN GASTRIC CANCER CELLS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(3): 129-130. doi:
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- 1. Steeg PS, Beviacpua G, Kopper L, et al. Evidence for a novel gene associate with low tumor metastaticpotential. J Natl Cancer Inst, 1988; 80(3)∶200.
- 2. 高进主编.癌的侵袭与转移基础研究与临床. 第1版. 北京： 北京医科大学、中国协和医科大学联合出版社， 1996∶117～119.
- 3. 王吾如. 关于癌转移的分子病理学研究. 中华病理学杂志， 1994； 23(4)∶197.
- 4. 黎明星. nm23基因与肿瘤转移. 国外医学分子生物学分册， 1994； 16(2)∶73.
- 5. Myeroff LL, Markowitz SD. nm23into the basement (Menbrane). J Natl Cancer Inst, 1994; 86(24)∶1815.
- 6. 雷文东， 张汝刚， 闰水忠等. nm23基因在人肺癌中的表达及其与肺癌淋巴结转移的关系. 中华肿瘤杂志， 1994； 16(4)∶227.
