POLYMORPHONUCLEAR AGGREGATION OF LEUKOCYTE IN ACUTE CHOLANGITIS AND ITS ROLE IN HEPATIC DAMAGE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Huang Xiankai ¹ , Han Benli. ²

Department of General Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042;

Corresponding author：

Keywords：

Cholangitis; Hepatic damage; Polymorphonuclear

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The mumber of Polymorphonuclear leukocyte (PMN) in hepatic tissue increased in the rats with cholangitis, PMN infiltration was mainly in the hepatic sinus in the early stage; and PMN infiltration presented around the hepatocytes 12 hours after infection. Degeneration and necrosis of the hepatic cells was also observed in the rats with acute cholangitis. Only 40 percent of the rats survived 24 hours after infection. Depletion of circulating PMN decreased the damage and necrosis of hepatocytes and improving the survival rate of the infected rats. The results suggest that PMN infiltration plays an important role in hepatic damage in acute cholangitis.

Citation： Huang Xiankai,Han Benli.. POLYMORPHONUCLEAR AGGREGATION OF LEUKOCYTE IN ACUTE CHOLANGITIS AND ITS ROLE IN HEPATIC DAMAGE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(3): 146-147. doi: Copy

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1. Komatsu Y, Shiratori Y, Kawase T, et al. Role of polymorphonuclear leukocytesin galactosamine hepatitis: mechanism of adherence to hepatic endothelial cell. Hepatology, 1994; 20(6)∶1548.
2. Essani NA, Fisher MA, Farhood A, et al. Cytokineinduced upregulation of hepatic intercellular adhesion moleculel messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure. Hepatology, 1995; 21(6)∶1632.
3. Miller VM, Komori K, Burnett JC, et al. Differential sensitivity to endothelin on canine arteries and veins. Am J Physiol, 1989; 257(8)∶H1127.
4. Homma S, Miyauchi T, Sugishita Y, et al. Vasocon strictoref fects of endothelin1 on myocardium microcirculation studied by the langendorff perfusion method: differential sencitivities among microvessels. Microvascular Research, 1992; 43(2)∶205.
5. Weichert W, Breddin HK. PAFacether antagonist and laser induced thrombin in rat mesenteric vessels. Haemostasis, 1989; 19(2)∶229.
6. Selak MA, Smith JB. Platelet activating factor induced calciu moblization in human platelets and neutrophils: effects of PAFacether antagonists. J Lipid Mediators, 1989; 20(1)∶152.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

POLYMORPHONUCLEAR AGGREGATION OF LEUKOCYTE IN ACUTE CHOLANGITIS AND ITS ROLE IN HEPATIC DAMAGE

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