TENASCIN EXPRESSION IN ATYPICAL HYPERPLASIA OF MAMMARY AND INFILTRATING DUCTAL BREAST CANCER_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Han Xiaorong , Jiang Jun , Ma Hongmin.

Department of General Surgery, South West Hospital, Third Military Medical University, Chongqing 400038;

Corresponding author：

Keywords：

Atypical hyperplasia; Breast cancer; Tenascin

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To investigate the changes of tenascin (TN) expression during the course of canceration through atypical hyperplasia of breast epithelia. The SP immunohistochemical method was used to study TN expresson in 50 different breast tissues. Results: There was no TN expression in normal breast and grade Ⅰ hyperplasia; immunostaining of TN was detected in 2 cases with grade Ⅱ atypical hyperplasia; the expression of TN in grade Ⅲ atypical hyperplasia (80%) and infiltrating ductal breast cancer (90%) was significantly higher than that in grade Ⅱ atypical hyperplasia (20%); and immunostaining of TN was detected in part of the cancer cells. Conclusion: These results suggest that TN expression in the stroma of serious atypical hyperplasia may play a role in limiting the outgrowth of hyperplastic epithelia.

Citation： Han Xiaorong,Jiang Jun,Ma Hongmin.. TENASCIN EXPRESSION IN ATYPICAL HYPERPLASIA OF MAMMARY AND INFILTRATING DUCTAL BREAST CANCER. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 261-262. doi: Copy

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6.	Sakakura T, Kusakabe M. Can tenascin be rebundant in cancer development? Perspect Dev Neurobiol, 1994; 2(1)∶111.
7.	Jahkola T, Toivonen T, Von Smitten K, et al. Expression of tenascin in invasion border of early breast cancer correlates with higher risk of destant metastasis. Int J Cancer, 1996; 69(6)∶445.
8.	Yoshida T, Ishihara A, Hirokawa Y, et al. Tenascin in breast cancer development is epithelial tenascin a marker for poor prognosis? Cancer Lett, 1995; 90(1)∶65.
9.	Kalembey I, Yoshida T, Iriyama KT, et al. Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. Int J Dev Biol, 1997; 41(4)∶569.
10.	Meiners S, Marone M, Rittenhouse JL, et al. Regulation of astrocytic tenascin by basic fibroblast growth factor. Devl Biol, 1993; 160(2)∶480.
11.	Chiquet ER, Hagios S. The complexity in regulating the expression of tenascin. Bioessays, 1995; 17(10)∶873.
12.	GonzalezSancho JM, Alvarez DM, Caelles C, et al. Inhibition of tenascinC expression in mammary epithelial cells by thyroid hormone. Mol Carcinog, 1999; 24(2)∶99.

1. ChiquetEhrismann R. Tenascins, a growing family of extracellular matrix proteins. Experientia, 1995; 51(910)∶853.
2. Page DL. Cancer risk assessment in benign breast biopsies. Human Pathol, 1986; 17(9)∶871.
3. Erickson HP. TenascinC， tenascinR, tenascinX—a family of talented proteins in search of function. Curr Opin Cell Biol, 1993; 5(5)∶869.
4. Chiquet ER, Makie EJ, Pearson CA, et al. Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesis. Cell, 1986; 47(1)∶131.
5. Iskaros BF, X Hu, Sparano JA, et al. Tenascin pattern of expression and established prognostic factors in invasive breast carcinoma. J Surg Oncol, 1998; 68(2)∶107.
6. Sakakura T, Kusakabe M. Can tenascin be rebundant in cancer development? Perspect Dev Neurobiol, 1994; 2(1)∶111.
7. Jahkola T, Toivonen T, Von Smitten K, et al. Expression of tenascin in invasion border of early breast cancer correlates with higher risk of destant metastasis. Int J Cancer, 1996; 69(6)∶445.
8. Yoshida T, Ishihara A, Hirokawa Y, et al. Tenascin in breast cancer development is epithelial tenascin a marker for poor prognosis? Cancer Lett, 1995; 90(1)∶65.
9. Kalembey I, Yoshida T, Iriyama KT, et al. Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study. Int J Dev Biol, 1997; 41(4)∶569.
10. Meiners S, Marone M, Rittenhouse JL, et al. Regulation of astrocytic tenascin by basic fibroblast growth factor. Devl Biol, 1993; 160(2)∶480.
11. Chiquet ER, Hagios S. The complexity in regulating the expression of tenascin. Bioessays, 1995; 17(10)∶873.
12. GonzalezSancho JM, Alvarez DM, Caelles C, et al. Inhibition of tenascinC expression in mammary epithelial cells by thyroid hormone. Mol Carcinog, 1999; 24(2)∶99.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

TENASCIN EXPRESSION IN ATYPICAL HYPERPLASIA OF MAMMARY AND INFILTRATING DUCTAL BREAST CANCER

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