To evaluate the effect of intercellular adhesiveness molecule-1 (ICAM-1), E-selectin on hepatic microcirculation in acute cholangitis. The Changes of hepatic tissue, content of blood flow and Evan′s blue (EB) in hepatic tissue in acute cholangitis were determinated. Results: The number of PMN in hepatic tissue and sinusin increased, degenaration and necrosis of the hepatic cells and hepatic sinusoidal endothelial cells and content of blood flow in liver were reduced, and content of EB in hepatic tissue increased remarkbly in the rats with acute cholangitis. Pretreatment of anti ICAM-1 and E-selectin mAb reduced the damage of hepatic microcirculation. Conclusion: ICAM-1 and E-selectin may play an important role in damage to hepatic microcirculation in acute cholangitis.
Citation：
Huang Xiankai,Han Benli.. THE EFFECT OF INTERCELLULAR ADHESIVENESS MOLECULE-1， E-SELECTIN ON HEPATIC MICROCIRCULATION IN ACUTE CHOLANGITIS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(5): 270-272. doi:
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- 1. 田牛主编. 微循环方法学. 北京： 原子能出版社， 1987∶35～39.
- 2. 金伯泉主编. 细胞和分子免疫学. 北京： 世界图书出版公司， 1994∶35～47.
- 3. Weichert W, Breddin HK. PAFacether antagonist and laser induced thrombin in rat mesenteric vessels. Haemostasis, 1989; 19(2)∶229.
- 4. Selak MA, Smith JB. Platelet activiting factor induced calciu moblization in human platelets and neutrophils: effects of PAFacether antagonists. J Lipid Mediators, 1989; 24(1)∶152.
- 5. Homma S, Miyauchi T, Sugishita Y, et al. Vasoconstrictor effects of endothelin1 on myocardium microcirculation studied by the langendorff perfusion method: differential sensitivities among microvessels. Microvascular Research, 1992; 43(2)∶205.
