EVALUATION OF HUMAN GROWTH HORMONE ON GASTRIC AND COLONIC CANCER PATIENTS AFTER SURGERY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Gerneral Surgery, The Second Affiliated Hospital, Kunming Medical College, Kunming 650101

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To study the effects of human growth hormone on protein catabolic state of gastric and colonic cancer patients after surgical intervention and whether it can improve the postoperative host immune function and reduce the postoperative fatigue syndrome (POF) by using rhGH. Thirtyeight gastric and colonic cancer patients (21 cases of gastric cancer; 17 cases of colonic cancer) were diveided into control group (n＝18) and rhGHtreated group (n＝20). All the patients were performed resection and treated by early postoperative intraperitoneal thermochemotherapy (EPIC) and total parenteral nutrition (TPN). Subcutaneous injections of 8 U rhGH at 9∶30 am was administered to the rhGHtreated group (six days) at the same time. Results: In the control group, a significant decrease in serum levels of albumin, prealbumin, transferri, IgG, IgA, IgM and CD＋３, CD＋4, CD＋8 were observed after operation (Ｐ＜0.01). In the rhGHtreated group, CD＋３, CD＋4 and CD＋8 raised significantly and the other did not change significantly. The postoperative vigour state of the patient was better than that in the control group. In the control group, pronouced weight loss of 3-5 kg, was detected on the 10th pastoperative day, while the weight loss was 1-2 kg in the rhGHtreated group (Ｐ＜0.01). Conclusion: The treatment with rhGH together with TPN and EPIC not only overcomes the protein catabolism of the cancer patient after operation by increasing protein synthesis, but also improves postoperative host immune function, reduces POF, and can raise the killing effect of chemotherapy on cancer cells, enhances the tolerance to chemotherapy.

Citation： Chen Jiayong,Zhang Jie,Tan Jing,et al.. EVALUATION OF HUMAN GROWTH HORMONE ON GASTRIC AND COLONIC CANCER PATIENTS AFTER SURGERY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1999, 6(6): 365-367. doi: Copy

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3.	Wilmore DW, Moylan JA, Bristow BF, et al. Anabolic effects of human growth hormone and high caloric feeding following thermal injury. Surg Gynecol Obstet, 1974; 138(6)∶87.
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5.	Rapaport R, Sills IN, Green L, et al. Detection of human growth hormone receptors on IM9 cell s and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormonebinding protein levels. J Clin Endocrinol Metab, 1995; 80(9)∶2612.
6.	Gelato MC. Growth hormoneinsulinlike growth factor I and immuune function. Trends Endocrinol Metab, 1993; 4(6)∶106.
7.	Bozzola M, Valtorta A, Moretta A, et al. In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr, 1990; 117(4)∶596.
8.	Lee PD, Pivarnik JM, Bukar JG, et al. A randomized, placebocontrolled trial of combined insulinlike growth factor I and low dose growth homone for wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab, 1996; 81(8)∶2968.
9.	VaraThorbeck TR, RuizRequena E, Guerrero JA. Effects of human growth hormone on the catabolic state after surgical trauma. Horm Res, 1964; 45(6)∶55.
10.	Christensen T, Kehlet H. Postoperative fatigue. World J Surg, 1993; 17(2)∶220.
11.	Schroeder D, Hill GL. Predicting postoperative fatigue, importance of preoperative factors. World J Surg, 1993; 17(2)∶226.
12.	Ogilvy Stuart AL, Shalet SM. Tumor occurrence and recurrence. Hmor Res, 1992; 38(Suppl 1)∶50.
13.	任建安，姜军，顾军等. 营养支持加用生长抑素、生长激素促进肠外瘘快速愈合. 肠内与肠外营养， 1998； 3(5)∶125.

1. Stress ST, Beddoe AH, Hill GT, et al. Aggressive nutritional support does not prevent protein loss depise fat gain septic intensive care patient. J Trauma, 1987; 27(3)∶262.
2. Phillips LS. Nutrition, somatomedins and the brain. metabolism, 1986; 35(8)∶78.
3. Wilmore DW, Moylan JA, Bristow BF, et al. Anabolic effects of human growth hormone and high caloric feeding following thermal injury. Surg Gynecol Obstet, 1974; 138(6)∶87.
4. Lesniak NA, Roth J, Gorden P, et al. Human growth hormone radeoreceptor assay using cultured human lymphocytes. Nature (New Biol), 1973; 241(3)∶20.
5. Rapaport R, Sills IN, Green L, et al. Detection of human growth hormone receptors on IM9 cell s and peripheral blood mononuclear cell subsets by flow cytometry: correlation with growth hormonebinding protein levels. J Clin Endocrinol Metab, 1995; 80(9)∶2612.
6. Gelato MC. Growth hormoneinsulinlike growth factor I and immuune function. Trends Endocrinol Metab, 1993; 4(6)∶106.
7. Bozzola M, Valtorta A, Moretta A, et al. In vitro and in vivo effect of growth hormone on cytotoxic activity. J Pediatr, 1990; 117(4)∶596.
8. Lee PD, Pivarnik JM, Bukar JG, et al. A randomized, placebocontrolled trial of combined insulinlike growth factor I and low dose growth homone for wasting associated with human immunodeficiency virus infection. J Clin Endocrinol Metab, 1996; 81(8)∶2968.
9. VaraThorbeck TR, RuizRequena E, Guerrero JA. Effects of human growth hormone on the catabolic state after surgical trauma. Horm Res, 1964; 45(6)∶55.
10. Christensen T, Kehlet H. Postoperative fatigue. World J Surg, 1993; 17(2)∶220.
11. Schroeder D, Hill GL. Predicting postoperative fatigue, importance of preoperative factors. World J Surg, 1993; 17(2)∶226.
12. Ogilvy Stuart AL, Shalet SM. Tumor occurrence and recurrence. Hmor Res, 1992; 38(Suppl 1)∶50.
13. 任建安，姜军，顾军等. 营养支持加用生长抑素、生长激素促进肠外瘘快速愈合. 肠内与肠外营养， 1998； 3(5)∶125.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EVALUATION OF HUMAN GROWTH HORMONE ON GASTRIC AND COLONIC CANCER PATIENTS AFTER SURGERY

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