mAbCD28 PLAYS AN IMMUNOSUPPRESSIVE ROLE IN ALLOGRAFT TRANSPLANTATION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Xiao Yi ¹ , Zhu Yu ¹ , Wang Shuhui. ²

Department of Surgery, Beijing Union Medical College Hospital, Beijing 100730;

Corresponding author：

Keywords：

CD28; Costimulatory pathway; Parathyroid gland transplantation; Transplant immunology

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

To verify the role of mAbCD28 in allograft transplantation. The biological action of mAbCD28 had been tested in mixed-lymphocyte-reaction and parathyroid gland allotranplantation in rats. Results: mAbCD28 could significantly suppress the proliferation of T cells in vitro and prolong the survival time of allograft in vivo. The results showed that mAbCD28 could block the costimulatory signals transmitted by CD28 molecules, and played an immunosuppressive role in parathyroid gland transplantation in rats.

Citation： Xiao Yi,Zhu Yu,Wang Shuhui.. mAbCD28 PLAYS AN IMMUNOSUPPRESSIVE ROLE IN ALLOGRAFT TRANSPLANTATION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 260-262. doi: Copy

1.	Linsley PS, Ledbetter JA. The role of the CD28 receptor during T cell responses to antigen. Annu Rev Immunol, 1993; 11∶191.
2.	陈力真，王树蕙，张云等.人化SCID鼠的建立及其对脊髓灰质炎病毒的免疫应答.中华微生物学和免疫学杂志，1995； 15∶82.
3.	Martin PJ, Ledbetter JA, Morishita Y, et al. A 44 kilodalton cell surface homodimer regulates interleukin 2 production by activated human T lymphocytes. J Immunol, 1986; 136∶3282.
4.	Damle NK, Doyle LV, Grosmaire LS, et al. Differential regulatory signals delivered by antibody binding to the CD28 (Tp44) molecule during the activation of human T lymphocytes. J Immunol, 1988; 140∶1753.
5.	Lin H, Bolling SF, Linsley PS, et al. Longterm acceptance of major histocompatbility complex mismatched cardiac allografts induced by CTLA4 Ig plus donorspecific transfusion. J Exp Med, 1993; 178∶1801.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

mAbCD28 PLAYS AN IMMUNOSUPPRESSIVE ROLE IN ALLOGRAFT TRANSPLANTATION

Abstract Full text Figures/Tables Video References Cited by

Format

Content