In order to reduce the immunogenicity of parathyroid allografts and induce immunotolerance, we depleted Ⅰa＋ donor cells of rat parathyroid allografts by anti-Ⅰa monoclonal antibody plus complement, transplanted the treated glands underneath the capsule of the recipient kindey,and observed the median survival time (MST) of the allografts. Our results showed that the MST of the treated group were 60 days, compared with control group (MST:14 days), Ｐ＜0.01. This results indicate that rat parathyroid allografts survival can be prolonged dramatically by depletion of Ⅰa＋ donor cells.
Citation：
Zhang Taiping,Zhu Yu,Wang Shuhui,et al.. PROLONGATION OF SURVIVAL OF RAT PARATHYROID ALLOGRAFTS BY DEPLETION OF Ⅰa＋ DONOR CELLS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1998, 5(5): 263-264下转269. doi:
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- 1. Lafferty KJ, Prowse SJ, Simeonovic CJ. Immunobiology of tissue transplantation: a return to the passenger leukocyte concept. Ann Rev Immunol, 1983; 1(1)∶143.
- 2. 罗江明.甲状旁腺同种异体移植.中华器官移植杂志，1987； 8(1)∶45.
- 3. Faustman D, Hauptfeld V, Lacy PE, et al. Prolongation of murine islet allograft by pretreatment of islets with antibody directed to Ⅰa determinants. Proc Natl Acad Sci USA, 1981; 78(6)∶5156.
- 4. 罗江明，朱预.高氧培养甲状旁腺对大鼠同种移植腺体存活时间的影响.中华器官移植杂志，1988； 9(2)∶73.
