EXPERIMENTAL STUDY OF HIPPURIC ACID TEST AS AN INDICATOR OF HEPATIC ENERGY METABOLISM IN RABBIT WITH ACUTE OBSTRUCTIVE JAUNDICE_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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Department of Hepatobiliary Pancrese Surgery,The First Affiliated Hospital of Nanjing Medical University,Nanjing 210029;

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Keywords：

Hippuric acid test; Obstructive jaundice; Energy metabolism; Rabbit

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Aippuric acid test(HAT) and hepatic energy metabolism and mitochondrial oxidative phosphorylation activity in rabbit with acute obstractive jaunidce was studied.The result showed that the HAT values were decreased from 98.4±32.0mg/h to 32.7±17.6mg/h(P lt;0.001),energy charge(EC) decreased from 0.81±0.01 to 0.72±0.02(P lt;0.001),and phosphorylation rate(PR)decreased from 62.1V5.1 to 38.3V2.4(P lt;0.001).Correlation coefficients between HAT and EC was 0.786,(P lt;0.001).This result suggests that HAT can be used as an indicator of hepatic energy metabolism status in acute obstructive jaundice.

Citation： Zhang Feng,Yu Xueming,Wang Xuehao,et al.. EXPERIMENTAL STUDY OF HIPPURIC ACID TEST AS AN INDICATOR OF HEPATIC ENERGY METABOLISM IN RABBIT WITH ACUTE OBSTRUCTIVE JAUNDICE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(2): 63-67. doi: Copy

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1. Aogama H,Kamigama Y,Ukikusa M,et al.Clinical significance of hippurate-synthesizing capacity in surgical patients with liver disease:a metabolic tolerance test.J Lab Clin Med,1986;108(3):456.
2. Tanaka A,Feng Z,Inomoto T,et al.Kinetic analysis of imparied work-cost performace in jaundied rabbit liver.Res Exp Med.1995;195(5):77.
3. Morimoto T,Ozawa K.Channges in oxidative phosphrylation adenylate energy charge and respiratory components in chloramphemical treating regenerating rat liver.J Lab Clin Med,1986;107(1):10.
4. Ozawa K,Yamaoka Y.Changes in hepatic energy charge blood ketone body ratio and indocyanine green clearance in relation to DNA synthesis after hepatectomy.Life Science,1982;11:647.
5. Gatley ST,Sherratt SA.The synthesis of hippurate from benzoate and glycine by rat liver mitochondria.Biochem J,1977;166(1):39.
6. Couger ML.Mechanism of bilirubin toxicity on tissue culture cell.Biochem Med,1971;5:1.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPERIMENTAL STUDY OF HIPPURIC ACID TEST AS AN INDICATOR OF HEPATIC ENERGY METABOLISM IN RABBIT WITH ACUTE OBSTRUCTIVE JAUNDICE

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