EXPERIMENT OF STUDY OF DONG LI SAN ON GALLSTONE PREVENTION_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Zhang Jihong ¹ , Yang kezhen ² , Han Benli. ²

Department of Hepatobiliary Surgery,General Hospital of Guangzhou Military Command,Guangzhou 510010;

Corresponding author：

Keywords：

Cholelithiasis; Dong Li San; Prevention

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Thirty seven rabbits were randomly divided into three groups fed with different feeds,the basic feed group as a control,high cholesterol group(feed containing 1.2% cholesterol)and high cholesterol feed added to Dong Li San which is a chinese medicine that can promote the contracition of gallbladder.All animals were fed with the corresponding feeds for four weeks.The results showed that 12 out of 14 rabbits in the high cholesterol group developed gallstone and 2 of 10 rabbits in the high cholesterol and Dong Li San feeding group had gallstone formation.The latter showed much higher emptying rate of gallbladder,lower level of mucin in the bile and much lower resistance to the cystic duct than those of the former.The results suggest that Dong Li San can effectively prevent gallstone formation by promoting gallbladder contraction ,reducing mucin in bile,decreasing cystic duct resistance and promoting the emptying capacity of gallbladder.

Citation： Zhang Jihong,Yang kezhen,Han Benli.. EXPERIMENT OF STUDY OF DONG LI SAN ON GALLSTONE PREVENTION. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(2): 68-70. doi: Copy

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9.	Pitt HA,Doty JE,Denbesten L,et al.Stasis before gallstone formation:altered gallbladder compliance or cystic duct resistance.Am J Surg,1982;143:144.
10.	Lee SP,LaMont JT,Carey MC.Organ culture of prairie dog gallbladder increased mucus synthesis and secretion is induced by lithogenic bile.Gastroenterology,1979;76(Abstr):1183.

1. Pomeramz IS,Shaffer EA.Abnormal gallbladder emptying in a subgroup of patient with gallstones.Gastroenterology,1985;88:787.
2. Doty JE,Pitt HA,Kuchencker SL,et al.Impaired gallbladder emptying before gallstone formation in the prairie dog.Gastroenterology,1987;85:168.
3. Pellgrini CS,Ryan T,Broderick W,et al. Gallbladder filling and emptying during cholesterol gallstone formation in the prairie dog.Gastroenterology,1986;90:143.
4. Yong F,Frank G,Norman W,et al.Gallbladder contractility and mucus secretion after cholester feeding in the prairie dog.Surgery,1986;100(5):900.
5. Fridhandler TM,Davison IS,Shaffer EA.Defective gallbladder contractility in the ground spurirrel and prairie dog during the early stages of cholesterol gallstone formation.Gastroenterology,1983;85:830.
6. 裴德恺,高静涛.胆结石的中药排石、溶石和防石研究.中西医结合杂志,1988;8(4):251.
7. 宋甫春,施维锦.中药防治胆结石的实验研究近况.上海中医杂志,1991;9:30.
8. 叶望云,李鸣真,潘恪如等.中医“下法”的利胆排石作用的实验研究.武汉医学院学报,1981;40:55.
9. Pitt HA,Doty JE,Denbesten L,et al.Stasis before gallstone formation:altered gallbladder compliance or cystic duct resistance.Am J Surg,1982;143:144.
10. Lee SP,LaMont JT,Carey MC.Organ culture of prairie dog gallbladder increased mucus synthesis and secretion is induced by lithogenic bile.Gastroenterology,1979;76(Abstr):1183.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPERIMENT OF STUDY OF DONG LI SAN ON GALLSTONE PREVENTION

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