Effect of radical operation on expression of interleukin-2(IL-2)mRNA and production of IL-2 were markedly reduced preoperatively and four weeks after operation,expression of IL-2 mRNA significantly enhanced,but it was still lower than that in the normal group.Production of IL-2 nearly reached normal level,When PBL was activated by phytohemagglutinin(PHA),expresseion of IL-2 mRNA and production of IL-2 were much higher than that in non-activated PBL.These results suggested that expression of IL-2 were much higher than that in non-activated PBL.These results suggested that expression of IL-2 mRNA and production of IL-2 are dificient in gastric cancer patients,and radical surgery will help them to recover and they can also be improved through activation with PHA.
Citation：
Xu Zekuan,Xu Shunfu,Zhang Feng.. EXPRESSION OF INTERLEUKIN-2 mRNA IN PERIPHERAL BLOOD LYMPHOCYTE PRE-AND POST-OPERATIVE OF GASTRIC CANCER PATIENT. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(2): 98-99. doi:
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- 2. Brik PE,Grimm PC.Rapid nonradioactive in situ hybridization for IL-2 mRNA with riboprobes generated using the polymerase chain reaction.J Immunol Methods,1994;167:83.
- 3. Xu X,Beckman I,Bradley J,et al.Age-related changes in the expression of IL-2 and high-affinity IL-2 binding sites.Int Arch Allergy Immunol,1993;102:224.
- 4. Vitolo D,Letesisier EM,Kohnson JT,et al.Immunologic effector cells in head and neck cancer.Monogr Natl Cancer Inst,1992;13:203.
