•  Laboratory of Surgery,The First Hospital of Guangxi Medical University,Nanning 530027;
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In order to raise the efficiency of chemotherapy on malignant tumor,we treated transplanted hepatocarcinomabearing mice with Ge132(organic germanium).The results were∶① in the group of highdosage Ge132,the carcinostatic rate was 310%,+++ white blood cell(WBC)infiltration found in transplanted tumor was 727%,and the serum superoxide dismutase (SOD) activity rate was 121 Nu/ml; ② in the control group with normal saline solution (NS),+++ WBC infiltration found in tumor was 36.4%, the serum SOD activity rate was 81 Nu/ml,and there was significant difference (P<0.05) between the two groups;③ in group of cyclophosphamide administration,the carcinostatic rate was 37.0%,+++ WBC infiltration found in the tumor was 27.3%,and the serum SOD activity rate was 102 Nu/ml;and ④ highdosage Ge132 in combination with cyclophosphamide,showed a carcinostatic rate of 45.0%,+++ WBC infiltration found in tumor was 54.5%,the serum SOD activity was 142 Nu/ml.In comparison between group 2 and 5,there were significant differance (P<0.05) in both tissue WBC infiltration and SOD activity.These results suggest that highdosage Ge132 treatment can enhance the cell mediated immunity and activity of serum SOD of transplanted hepatocarcinomabearing mice with certain anticarcinoma effect.

Citation: 李佳荃,凌卓莹,凌鸿英. INFLUENCE OF ORGANIC GERMANIUM ON ANTIHEPATOCARCINOMA EFFECT OF CYCLOPHOSPHAMIDE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(3): 132-134. doi: Copy