In order to raise the efficiency of chemotherapy on malignant tumor,we treated transplanted hepatocarcinomabearing mice with Ge132(organic germanium).The results were∶① in the group of highdosage Ge132,the carcinostatic rate was 310%,+++ white blood cell(WBC)infiltration found in transplanted tumor was 727%,and the serum superoxide dismutase (SOD) activity rate was 121 Nu/ml; ② in the control group with normal saline solution (NS),+++ WBC infiltration found in tumor was 36.4%, the serum SOD activity rate was 81 Nu/ml,and there was significant difference (P<0.05) between the two groups;③ in group of cyclophosphamide administration,the carcinostatic rate was 37.0%,+++ WBC infiltration found in the tumor was 27.3%,and the serum SOD activity rate was 102 Nu/ml;and ④ highdosage Ge132 in combination with cyclophosphamide,showed a carcinostatic rate of 45.0%,+++ WBC infiltration found in tumor was 54.5%,the serum SOD activity was 142 Nu/ml.In comparison between group 2 and 5,there were significant differance (P<0.05) in both tissue WBC infiltration and SOD activity.These results suggest that highdosage Ge132 treatment can enhance the cell mediated immunity and activity of serum SOD of transplanted hepatocarcinomabearing mice with certain anticarcinoma effect.
Citation: 李佳荃,凌卓莹,凌鸿英. INFLUENCE OF ORGANIC GERMANIUM ON ANTIHEPATOCARCINOMA EFFECT OF CYCLOPHOSPHAMIDE. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1997, 4(3): 132-134. doi: Copy