We established acute cholangitis and endotoxiemia in 18 rabbits by ligating the common bile duct and injecting E coli(O111B4 strain)into the common bile duct. After perfusion through activated charcoal via femoral artery-vein pathway, the average blood levels of endotoxin decreased sighificantly from 2.24Eu/ml to 0.17Eu/ml(P lt;0.001). This result suggested that blood perfusion through activated charcoal may be a promising therapy for acute endotoxemia.
Citation： Feng Guangnan,Liu Jian,Wu Ping,et al.. THE CLEARANCE EFFECT OF BLOOD PERFUSION ON EXPERIMENTAL ENDOTOXIMIA. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(4): 203-204. doi: Copy