THE EXPERIMENT STUDY AND CLINICAL APPLICATION OF TREATMENT OF CANCEROUS ASCITES WITH INTRAPERITONEAL HYPERTHERMIC DOUBLE DISTILED WARTER AND CIS DIAMMINEDICHLORO-PLATINUM PERFUSION FOR GASTRIC CANCER PATIENTS AFTER RADICAL GASTRECTOMY_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Department of General Surgery,The First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041;

Corresponding author：

Keywords：

Intraperitoneal perfusion; Hyperthermic double distiled water; Cis-diammnedichloro-Platinum; Gastric cancer; Clinical application

Video：

Export PDF Favorites Scan Get Citation

Abstract Full text Figures/Tables Video References Cited by

To study the effect of intraperitoneal hyperthermic double distiled water and cis-diamminedichloro-platinum(DDP) perfusion to the peritoneal cancerous ascites,intraperitoneal injection of H22 cancer cells (2×107 tumor cell,each mouse) were performed in LACA mice. Five days after cancer cells injection, intraperitoneal perfusion of simple hypertherrnic (43℃) double distiled water(group Ⅰ) isotonic fluid (group Ⅱ ). DDP (group Ⅲ ), and hypertherrnic double distiles water perfusion combined with DDP (guoup Ⅳ ) were performed .The results showed that cancer cells in the peritoneal cavity of LACA mice were seriously damaged, the production of ascites was markedly inhibited and the survival days of LACA mice were prolonged in all groups . .The intraperitoneal hyperthermic double distilled water perfusion with DDP group showed more effective result as compared with the other groups,Only 1 peritoneal implanted dissemination was found after treatment in this group,Basing on the experimental from September 1991 through September 1993,intraperitoneal hyperthermic double distiled water perfusion with DDP was used to treat 32 advanced gastric cancer patients after radical gastrectomy with satisfactory results.

Citation： Chen Zhixing,Chen Jiaping,Peng Deshu,et al.. THE EXPERIMENT STUDY AND CLINICAL APPLICATION OF TREATMENT OF CANCEROUS ASCITES WITH INTRAPERITONEAL HYPERTHERMIC DOUBLE DISTILED WARTER AND CIS DIAMMINEDICHLORO-PLATINUM PERFUSION FOR GASTRIC CANCER PATIENTS AFTER RADICAL GASTRECTOMY. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(3): 139-142. doi: Copy

1.	Fujimoto S, Shrestha RD,Kokubun M. Intraperitoneal hyperthermic perfusion combined with surgery effeetive for gastric cancer patients with peritoneal seeding .Ann Surg, 1988; 208 :36.
2.	Koga S, Hamazo ER,Maeta M.Prophylactic therapy for peritoneal recurrence of gastric cancer by contineous hyperthermic peritoneal perfusion with mitomycin C.Cancer, 1988;61:2329.
3.	Kaibara N. Hyperthermic peritoneal perfusion combined with anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer .Hepato-Gastrointerol, 1989; 36 :75.
4.	Fujimura T, Yonemura Y, Fushida s. Continuous hyperthermic peritoneal perfusion for the treatment of peritoneal dissemination in gastric cancers and subsequent second-look operation .Cancer, 1990;, 65 :65.
5.	徐淑云主编.药理实验方法学.第2版.北京：人民卫生出版社，1991：1424～430.
6.	Trave F,Rustum YM,Boransen T.Synergistic antitumor activity of cisplatin(DDP)and 5-fluorouracil(Fura) in mice bearin leakemia L1210 cells . Proc Annu-Meet Am Assoc Cancer Res,1985;26:322.
7.	徐淑云.临床用药指南.合肥：安徽科学技术出版社，1989：8～10.
8.	Howell SB, Pfeifle CE, Wang WE. Intraperitoneal cisdiamminediochloroplatinum with systemic thiosulfate protection .Cancer Res, 1983; 43 :1426.
9.	Litsuka Y,Kaneshima﹒S,Tanida O.Intraperitoneal free cancer cells and their viability in gastric cancer .Cancer,1979;44:1476.

1. Fujimoto S, Shrestha RD,Kokubun M. Intraperitoneal hyperthermic perfusion combined with surgery effeetive for gastric cancer patients with peritoneal seeding .Ann Surg, 1988; 208 :36.
2. Koga S, Hamazo ER,Maeta M.Prophylactic therapy for peritoneal recurrence of gastric cancer by contineous hyperthermic peritoneal perfusion with mitomycin C.Cancer, 1988;61:2329.
3. Kaibara N. Hyperthermic peritoneal perfusion combined with anticancer chemotherapy as prophylactic treatment of peritoneal recurrence of gastric cancer .Hepato-Gastrointerol, 1989; 36 :75.
4. Fujimura T, Yonemura Y, Fushida s. Continuous hyperthermic peritoneal perfusion for the treatment of peritoneal dissemination in gastric cancers and subsequent second-look operation .Cancer, 1990;, 65 :65.
5. 徐淑云主编.药理实验方法学.第2版.北京：人民卫生出版社，1991：1424～430.
6. Trave F,Rustum YM,Boransen T.Synergistic antitumor activity of cisplatin(DDP)and 5-fluorouracil(Fura) in mice bearin leakemia L1210 cells . Proc Annu-Meet Am Assoc Cancer Res,1985;26:322.
7. 徐淑云.临床用药指南.合肥：安徽科学技术出版社，1989：8～10.
8. Howell SB, Pfeifle CE, Wang WE. Intraperitoneal cisdiamminediochloroplatinum with systemic thiosulfate protection .Cancer Res, 1983; 43 :1426.
9. Litsuka Y,Kaneshima﹒S,Tanida O.Intraperitoneal free cancer cells and their viability in gastric cancer .Cancer,1979;44:1476.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

THE EXPERIMENT STUDY AND CLINICAL APPLICATION OF TREATMENT OF CANCEROUS ASCITES WITH INTRAPERITONEAL HYPERTHERMIC DOUBLE DISTILED WARTER AND CIS DIAMMINEDICHLORO-PLATINUM PERFUSION FOR GASTRIC CANCER PATIENTS AFTER RADICAL GASTRECTOMY

Abstract Full text Figures/Tables Video References Cited by

Format

Content