EXPRESSION AND SIGNIFICANCE OF NM23 PROTEIN IN HUMAN THYROID CARCINOMAS_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

Authors：

Chen Yanchang , Chen Daliang , Yin Fengshi.

Department of General Surgery Union Affiliated Hospital of Fujian Medical College, Fuzhou 350001;

Corresponding author：

Keywords：

Thyroid neoplesm; Gene expression; Prognosis

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We have used immunphistochemical SP method to detect the expression of nm23 gene protein in human thyroid tissues from 86 carcinomas, 20 adenomas and 25 carcinomatous adjecent tissues. The results showed the positive staining rate were 73.3%, 40.0%and 16. 0% respective (P lt; 0. 005). Although the expression of nm23 protein had no association with the cervical lymph node metas-tases,it was significantly concordant with the tumor cell diffierentiation (P lt;0. 01) ,tumer capsule (P lt; 0. 05) and TNM stage (P lt;0.05).In addition, the patient‘s average survival time in nm23-positive cases was longer than that in nm23-negative ones (P lt;0.01).This data suggest that nm23 gene may play an important role in thyroid carcinogenesis and the expression of nm23 protein would be an useful marker in assessing the prognosis of the thyroid carcinomas.

Citation： Chen Yanchang,Chen Daliang,Yin Fengshi.. EXPRESSION AND SIGNIFICANCE OF NM23 PROTEIN IN HUMAN THYROID CARCINOMAS. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1996, 3(3): 143-145. doi: Copy

1.	Steeg PS, Bevilaequa G, Kopper L,et al. Evidence for a novel gene associated with low tumor metastatic potential . J Natl Cancer Inst, 1988;80 :200.
2.	Nakayama T,Ghtsuru A,Nakao K,et al. Expression in human hepatocellular carcinoma of nucleoside disphosphate kinase,ahomologue of the nm23 gene product.J Natl Cancer Inst ,1992;84:1349.
3.	Tokunaga Y,Urano T,Furukawa K.et al. Reduced expres sion of nm 23-H1 but not of nm23-H2, is concordant with fro quency of lymph-node metastasis of human breast cancer .Int j Cancer, 1993； 55 :66.
4.	雷文东，张汝刚，闫水忠等. nm23基因在人肺癌中的表达及其与肺癌淋巴结转移的关系. 中华肿瘤杂志, 1994;16(4):277.
5.	Zou M, Shi Y, Al-Sedairy, et al. High levels of nm23 gene expression in advance stage of thyroid carcinomas .Br J Cancer, 1993;68 :385.
6.	Luo W, Matsuo K, Nagayama Y, et al. Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metas tasis .Thyroid, 1993;3 :105.
7.	Arai T, Watanabe M,Onoclera M,et al. Reduced nm23 –H1 messenger RNA expression in metastic lymph nodes from patients with papillary carcinoma of the thyroid .Am J Pathol, 1993;142 :1938.
8.	Cohn KH, Wang F.Lapaix FD,et al. Association of nm23 H1 allelic deletions with distant metastases in colorectal carcinoma .Lancet, 1991； 388 :722.
9.	Wang L,Patel U, Ghosh L,et al. Mutation in the nm 23gene is associated with metastasis in colorectal carcinoma .Cancer Res, 1993;53 :717.

1. Steeg PS, Bevilaequa G, Kopper L,et al. Evidence for a novel gene associated with low tumor metastatic potential . J Natl Cancer Inst, 1988;80 :200.
2. Nakayama T,Ghtsuru A,Nakao K,et al. Expression in human hepatocellular carcinoma of nucleoside disphosphate kinase,ahomologue of the nm23 gene product.J Natl Cancer Inst ,1992;84:1349.
3. Tokunaga Y,Urano T,Furukawa K.et al. Reduced expres sion of nm 23-H1 but not of nm23-H2, is concordant with fro quency of lymph-node metastasis of human breast cancer .Int j Cancer, 1993； 55 :66.
4. 雷文东，张汝刚，闫水忠等. nm23基因在人肺癌中的表达及其与肺癌淋巴结转移的关系. 中华肿瘤杂志, 1994;16(4):277.
5. Zou M, Shi Y, Al-Sedairy, et al. High levels of nm23 gene expression in advance stage of thyroid carcinomas .Br J Cancer, 1993;68 :385.
6. Luo W, Matsuo K, Nagayama Y, et al. Immunohistochemical analysis of expression of nm23-H1/nucleoside diphosphate kinase in human thyroid carcinomas: lack of correlation between its expression and lymph node metas tasis .Thyroid, 1993;3 :105.
7. Arai T, Watanabe M,Onoclera M,et al. Reduced nm23 –H1 messenger RNA expression in metastic lymph nodes from patients with papillary carcinoma of the thyroid .Am J Pathol, 1993;142 :1938.
8. Cohn KH, Wang F.Lapaix FD,et al. Association of nm23 H1 allelic deletions with distant metastases in colorectal carcinoma .Lancet, 1991； 388 :722.
9. Wang L,Patel U, Ghosh L,et al. Mutation in the nm 23gene is associated with metastasis in colorectal carcinoma .Cancer Res, 1993;53 :717.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EXPRESSION AND SIGNIFICANCE OF NM23 PROTEIN IN HUMAN THYROID CARCINOMAS

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