EFFECTS OF CIRRHOTIC PORTAL HYPERTENSION AND THE DIFFERENT TYPES OF OPERATION ON THE FUNCTIONAL RESERVE OF THE LIVER IN THE RAT_CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

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The Center of Hepatobiliary Surgery, Southwest Hospital, The Third Militery Medical University, Chongqing 630038;

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Keywords：

Rat; Liver cirrhosis; Hepatic reserved function; Oral glucose tolerance test; Pancreatic glucagon lading test

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The wister rats with cirrhotic portal hypertension induced by carbon tetrachloride/ethanal were divided into four groups;①distal splenocaval shunt(DSCS);②portal azygous devascularization (PAD);③mesocaval shunt side to side (MCS);and ④the conrol. Oral glucose toleronce test (OGTT), and glucagon loading test (GLT) were performed on them. The results revealed that the hepatic reserve function of the rats with DSCS and PAD had significant difference as compared with the control (Ｐ＜0.05), but that of the rat with MCS had no significant difference as compared with the control (Ｐ＞0.05).The present study indicates that the hepatic reserve function of rats with DSCS and PAD is better than that of the rats with MCS.

Citation： ,al.. EFFECTS OF CIRRHOTIC PORTAL HYPERTENSION AND THE DIFFERENT TYPES OF OPERATION ON THE FUNCTIONAL RESERVE OF THE LIVER IN THE RAT. CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY, 1995, 2(4): 187-190. doi: Copy

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1. 葛西洋一.术前のrisk判定—硬变合并肝癌.た中心に.临床外科，1983；38：1289.
2. 吉田孝宣.肝机能总量判定检查法としてのフルカこよY负荷试验の意义.肝脏，1985；2：1146.
3. 大西俊郎.新しい肝脏机能预备力检查法の开发研究に关よる研究-glucagon负荷后の血中cyclic-Amp值解析による肝机能预备检查法.肝脏，1985；26：435.
4. 文天夫，郑光琪.糖耐量和胰岛素分泌试验对预测有癌手术风险的价值.中华外科杂志，1989；26：435.
5. 吕明德，黄洁夫.肝癌手术前肝储备功能预测的临床研究.中华外科杂志，1993；31(9)：532.
6. 吴孟超，杨广顺.大鼠肝硬变模型复制的研究.中华实验外科杂志，1984；1(4)：145.
7. 韩德伍编著.肝功能不全.第1版.北京：人民卫生出版社，1981：75.
8. Sherlock S. Progress report hepatic rections to drugs. Gut, 1979;20:643.
9. Krahebuhe S, Weber FL, Brass EP. Decreased hepatic glycogen content and accelerated response to starvation in rats with CCL4-induced cirrhosis. Hepatology, 1991;14(6):1189.
10. Schnneweis B. Energy metabolism in patients with acute and chronic liver disease. Hepatology, 1990;11:387.

CHINESE JOURNAL OF BASES AND CLINICS IN GENERAL SURGERY

EFFECTS OF CIRRHOTIC PORTAL HYPERTENSION AND THE DIFFERENT TYPES OF OPERATION ON THE FUNCTIONAL RESERVE OF THE LIVER IN THE RAT

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